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Insight into the Strong Antioxidant Activity of Deinoxanthin, a Unique Carotenoid in Deinococcus Radiodurans
Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, China
Received: 23 October 2010; in revised form: 3 November 2010 / Accepted: 7 November 2010 / Published: 10 November 2010
Abstract: Deinoxanthin (DX) is a unique carotenoid synthesized by Deinococcus radiodurans, one of the most radioresistant organisms known. In comparison with other carotenoids, DX was proven to exhibit significantly stronger reactive oxygen species (ROS)-scavenging activity, which plays an important role in the radioresistance of D. radiodurans. In this work, to gain deeper insights into the strong antioxidant activity of DX, the parameters characterizing ROS-scavenging potential were calculated by means of quantum chemical calculations. It was found that DX possesses lower lowest triplet excitation energy for its unique structure than other carotenoids, such as β-carotene and zeaxanthin, which endows DX strong potential in the energy transfer-based ROS‑scavenging process. Moreover, the H-atom donating potential of DX is similar to zeaxanthin according to the theoretical homolytic O-H bond dissociation enthalpy. Thus, the large number of conjugated double bonds should be crucial for its strong antioxidant activity.
Keywords: deinoxanthin; lowest triplet excitation energy; bond dissociation enthalpy; density functional theory
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Ji, H.-F. Insight into the Strong Antioxidant Activity of Deinoxanthin, a Unique Carotenoid in Deinococcus Radiodurans. Int. J. Mol. Sci. 2010, 11, 4506-4510.
Ji H-F. Insight into the Strong Antioxidant Activity of Deinoxanthin, a Unique Carotenoid in Deinococcus Radiodurans. International Journal of Molecular Sciences. 2010; 11(11):4506-4510.
Ji, Hong-Fang. 2010. "Insight into the Strong Antioxidant Activity of Deinoxanthin, a Unique Carotenoid in Deinococcus Radiodurans." Int. J. Mol. Sci. 11, no. 11: 4506-4510.