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Int. J. Mol. Sci. 2010, 11(11), 4175-4193; doi:10.3390/ijms11114175
Review

Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs

1,†
, 1,†
, 1, 1
, 2, 3, 2 and 1,*
Received: 15 September 2010; in revised form: 16 October 2010 / Accepted: 18 October 2010 / Published: 26 October 2010
(This article belongs to the Special Issue Biomarkers)
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Abstract: Early diagnosis of cancer is of pivotal importance to reduce disease-related mortality. There is great need for non-invasive screening methods, yet current screening protocols have limited sensitivity and specificity. The use of serum biomarkers to discriminate cancer patients from healthy persons might be a tool to improve screening programs. Mass spectrometry based proteomics is widely applied as a technology for mapping and identifying peptides and proteins in body fluids. One commonly used approach in proteomics is peptide and protein profiling. Here, we present an overview of profiling methods that have the potential for implementation in a clinical setting and in national screening programs.
Keywords: mass spectrometry; biomarker; MALDI-TOF; SELDI-TOF; colorectal cancer; breast cancer; screening; proteomics; magnetic beads mass spectrometry; biomarker; MALDI-TOF; SELDI-TOF; colorectal cancer; breast cancer; screening; proteomics; magnetic beads
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Huijbers, A.; Velstra, B.; Dekker, T.J.A.; Mesker, W.E.; Burgt, Y.E.M.; Mertens, B.J.; Deelder, A.M.; Tollenaar, R.A.E.M. Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs. Int. J. Mol. Sci. 2010, 11, 4175-4193.

AMA Style

Huijbers A, Velstra B, Dekker TJA, Mesker WE, Burgt YEM, Mertens BJ, Deelder AM, Tollenaar RAEM. Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs. International Journal of Molecular Sciences. 2010; 11(11):4175-4193.

Chicago/Turabian Style

Huijbers, Anouck; Velstra, Berit; Dekker, Tim J. A.; Mesker, Wilma E.; Burgt, Yuri E. M. van der; Mertens, Bart J.; Deelder, André M.; Tollenaar, Rob A. E. M. 2010. "Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs." Int. J. Mol. Sci. 11, no. 11: 4175-4193.



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