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• Huijbers, A
• Velstra, B
• Dekker, T
• Mesker, W
• Burgt, Y
• Mertens, B
• Deelder, A
• Tollenaar, R
• [+] on Google Scholar
• Huijbers, A
• Velstra, B
• Dekker, T
• Mesker, W
• Burgt, Y
• Mertens, B
• Deelder, A
• Tollenaar, R
• [+] on PubMed
• Huijbers, A
• Velstra, B
• Dekker, T
• Mesker, W
• Burgt, Y
• Mertens, B
• Deelder, A
• Tollenaar, R

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Int. J. Mol. Sci. 2010, 11(11), 4175-4193; doi:10.3390/ijms11114175

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Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs

Anouck Huijbers ^1,† , Berit Velstra ^1,† , Tim J. A. Dekker ¹ , Wilma E. Mesker ¹ , Yuri E. M. van der Burgt ² , Bart J. Mertens ³ , André M. Deelder ²  and Rob A. E. M. Tollenaar ^1,*

¹ Department of Surgery, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands ² Department of Parasitology, Biomolecular Mass Spectrometry Unit, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands ³ Department of Medical Statistics, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands ^† These authors contributed equally to this work.

* Author to whom correspondence should be addressed.

Received: 15 September 2010; in revised form: 16 October 2010 / Accepted: 18 October 2010 / Published: 26 October 2010

(This article belongs to the Special Issue Biomarkers)

Download PDF Full-Text [132 KB, uploaded 26 October 2010 17:03 CEST]

Abstract: Early diagnosis of cancer is of pivotal importance to reduce disease-related mortality. There is great need for non-invasive screening methods, yet current screening protocols have limited sensitivity and specificity. The use of serum biomarkers to discriminate cancer patients from healthy persons might be a tool to improve screening programs. Mass spectrometry based proteomics is widely applied as a technology for mapping and identifying peptides and proteins in body fluids. One commonly used approach in proteomics is peptide and protein profiling. Here, we present an overview of profiling methods that have the potential for implementation in a clinical setting and in national screening programs.

Keywords: mass spectrometry; biomarker; MALDI-TOF; SELDI-TOF; colorectal cancer; breast cancer; screening; proteomics; magnetic beads

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