Int. J. Mol. Sci. 2010, 11(10), 3942-3953; doi:10.3390/ijms11103942
Article

Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves

Leopoldina Leonor Fagundes 1 email, Glauciemar Del-Vechio Vieira 1 email, José de Jesus R. G. De Pinho 1 email, Célia Hitomi Yamamoto 1 email, Maria Silvana Alves 2 email, Paulo César Stringheta 3 email and Orlando Vieira De Sousa 1,* email
1 Departamento Farmacêutico, Faculdade de Farmácia e Bioquímica, Universidade Federal de Juiz de Fora, Campus Universitário, Martelos, 36036-330, Juiz de Fora, MG, Brazil 2 Departamento de Análises Clínicas, Faculdade de Farmácia e Bioquímica, Universidade Federal de Juiz de Fora, Campus Universitário, Martelos, 36036-330, Juiz de Fora, MG, Brazil 3 Departamento de Tecnologia de Alimentos, Centro de Ciências Exatas e Tecnológicas, Universidade Federal de Viçosa, Campus Universitário, 36571-000 - Viçosa, MG, Brazil
* Author to whom correspondence should be addressed.
Received: 17 September 2010; in revised form: 29 September 2010 / Accepted: 12 October 2010 / Published: 15 October 2010
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: Antinociceptive and anti-inflammatory activities of the Muehlenbeckia platyclada leaves’ ethanol extract were investigated in animal models. The extract (p.o.) reduced the number of abdominal contortions induced by acetic acid by 21.57% (400 mg/kg). After intraplantar injection of formalin, a dose of 400 mg/kg (p.o.) inhibited the time spent paw licking in the first phase (26.43%), while the second phase was inhibited by 10.90 and 36.65% at the doses of 200 and 400 mg/kg, respectively. The extract (p.o.) increased the reaction time on a hot plate at a dose of 400 mg/kg (32.68 and 40.30%) after 60 and 90 minutes of treatment, respectively. The paw edema was reduced by extract (p.o.) at doses of 100 (15.46 and 16.67%), 200 (22.68 and 25.64%) and 400 mg/kg (29.50 and 37.33%) after 3 to 4 h of carrageenan application, respectively. Doses of 100, 200 and 400 mg/kg (p.o.), administered 4 h after the carrageenan injection, reduced the exudate volume (11.28, 21.54 and 45.13%), while leukocyte migration was reduced by 21.21 and 29.70% at the doses of 200 and 400 mg/kg, respectively. These results indicate that the ethanol extract from M. platyclada may constitute a potential target for the discovery of new molecules with antinociceptive and anti-inflammatory activities that can be explored for their therapeutic use.
Keywords: Muehlenbeckia platyclada; Polygonaceae; antinociceptive activity; anti‑inflammatory activity

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MDPI and ACS Style

Fagundes, L.L.; Del-Vechio Vieira, G.; De Pinho, J.J.R.G.; Yamamoto, C.H.; Alves, M.S.; Stringheta, P.C.; De Sousa, O.V. Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves. Int. J. Mol. Sci. 2010, 11, 3942-3953.

AMA Style

Fagundes LL, Del-Vechio Vieira G, De Pinho JJRG, Yamamoto CH, Alves MS, Stringheta PC, De Sousa OV. Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves. International Journal of Molecular Sciences. 2010; 11(10):3942-3953.

Chicago/Turabian Style

Fagundes, Leopoldina Leonor; Del-Vechio Vieira, Glauciemar; De Pinho, José de Jesus R. G.; Yamamoto, Célia Hitomi; Alves, Maria Silvana; Stringheta, Paulo César; De Sousa, Orlando Vieira. 2010. "Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves." Int. J. Mol. Sci. 11, no. 10: 3942-3953.

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