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Int. J. Mol. Sci. 2010, 11(10), 3942-3953; doi:10.3390/ijms11103942
Article

Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves

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1 Departamento Farmacêutico, Faculdade de Farmácia e Bioquímica, Universidade Federal de Juiz de Fora, Campus Universitário, Martelos, 36036-330, Juiz de Fora, MG, Brazil 2 Departamento de Análises Clínicas, Faculdade de Farmácia e Bioquímica, Universidade Federal de Juiz de Fora, Campus Universitário, Martelos, 36036-330, Juiz de Fora, MG, Brazil 3 Departamento de Tecnologia de Alimentos, Centro de Ciências Exatas e Tecnológicas, Universidade Federal de Viçosa, Campus Universitário, 36571-000 - Viçosa, MG, Brazil
* Author to whom correspondence should be addressed.
Received: 17 September 2010 / Revised: 29 September 2010 / Accepted: 12 October 2010 / Published: 15 October 2010
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Antinociceptive and anti-inflammatory activities of the Muehlenbeckia platyclada leaves’ ethanol extract were investigated in animal models. The extract (p.o.) reduced the number of abdominal contortions induced by acetic acid by 21.57% (400 mg/kg). After intraplantar injection of formalin, a dose of 400 mg/kg (p.o.) inhibited the time spent paw licking in the first phase (26.43%), while the second phase was inhibited by 10.90 and 36.65% at the doses of 200 and 400 mg/kg, respectively. The extract (p.o.) increased the reaction time on a hot plate at a dose of 400 mg/kg (32.68 and 40.30%) after 60 and 90 minutes of treatment, respectively. The paw edema was reduced by extract (p.o.) at doses of 100 (15.46 and 16.67%), 200 (22.68 and 25.64%) and 400 mg/kg (29.50 and 37.33%) after 3 to 4 h of carrageenan application, respectively. Doses of 100, 200 and 400 mg/kg (p.o.), administered 4 h after the carrageenan injection, reduced the exudate volume (11.28, 21.54 and 45.13%), while leukocyte migration was reduced by 21.21 and 29.70% at the doses of 200 and 400 mg/kg, respectively. These results indicate that the ethanol extract from M. platyclada may constitute a potential target for the discovery of new molecules with antinociceptive and anti-inflammatory activities that can be explored for their therapeutic use.
Keywords: Muehlenbeckia platyclada; Polygonaceae; antinociceptive activity; anti‑inflammatory activity Muehlenbeckia platyclada; Polygonaceae; antinociceptive activity; anti‑inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Fagundes, L.L.; Del-Vechio Vieira, G.; De Pinho, J.J.R.G.; Yamamoto, C.H.; Alves, M.S.; Stringheta, P.C.; De Sousa, O.V. Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves. Int. J. Mol. Sci. 2010, 11, 3942-3953.

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