Abstract: Antinociceptive and anti-inflammatory activities of the Muehlenbeckia platyclada leaves’ ethanol extract were investigated in animal models. The extract (p.o.) reduced the number of abdominal contortions induced by acetic acid by 21.57% (400 mg/kg). After intraplantar injection of formalin, a dose of 400 mg/kg (p.o.) inhibited the time spent paw licking in the first phase (26.43%), while the second phase was inhibited by 10.90 and 36.65% at the doses of 200 and 400 mg/kg, respectively. The extract (p.o.) increased the reaction time on a hot plate at a dose of 400 mg/kg (32.68 and 40.30%) after 60 and 90 minutes of treatment, respectively. The paw edema was reduced by extract (p.o.) at doses of 100 (15.46 and 16.67%), 200 (22.68 and 25.64%) and 400 mg/kg (29.50 and 37.33%) after 3 to 4 h of carrageenan application, respectively. Doses of 100, 200 and 400 mg/kg (p.o.), administered 4 h after the carrageenan injection, reduced the exudate volume (11.28, 21.54 and 45.13%), while leukocyte migration was reduced by 21.21 and 29.70% at the doses of 200 and 400 mg/kg, respectively. These results indicate that the ethanol extract from M. platyclada may constitute a potential target for the discovery of new molecules with antinociceptive and anti-inflammatory activities that can be explored for their therapeutic use.
Keywords: Muehlenbeckia platyclada; Polygonaceae; antinociceptive activity; anti‑inflammatory activity
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Fagundes, L.L.; Del-Vechio Vieira, G.; De Pinho, J.J.R.G.; Yamamoto, C.H.; Alves, M.S.; Stringheta, P.C.; De Sousa, O.V. Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves. Int. J. Mol. Sci. 2010, 11, 3942-3953.
Fagundes LL, Del-Vechio Vieira G, De Pinho JJRG, Yamamoto CH, Alves MS, Stringheta PC, De Sousa OV. Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves. International Journal of Molecular Sciences. 2010; 11(10):3942-3953.
Fagundes, Leopoldina Leonor; Del-Vechio Vieira, Glauciemar; De Pinho, José de Jesus R. G.; Yamamoto, Célia Hitomi; Alves, Maria Silvana; Stringheta, Paulo César; De Sousa, Orlando Vieira. 2010. "Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves." Int. J. Mol. Sci. 11, no. 10: 3942-3953.