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Int. J. Mol. Sci. 2010, 11(1), 222-232; doi:10.3390/ijms11010222
Review

ERK in Learning and Memory: A Review of Recent Research

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Received: 16 December 2009 / Revised: 8 January 2010 / Accepted: 10 January 2010 / Published: 13 January 2010
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The extracellular signal-regulated kinase (ERK) pathway is a member of the mitogen-activated protein kinase (MAPK) superfamily, which is an important, highly conserved family of enzymes associated with cell membrane receptors and regulative targets. In the central nervous system, there is almost no mature neuronal proliferation and differentiation, but the regulation of MAPK and its upstream and downstream molecular pathways is still widespread, with the ERK signaling pathway being one of the most actively studied signal transduction pathways. It is activated by a variety of cell growth factors and substances which promote mitotic activity, and transmits extracellular signals from the cell surface to the nucleus, which transmission plays an important role in the process of cell proliferation and differentiation. In recent years, accumulating evidence has shown that the ERK signaling pathway has an important link with the higher functions of learning and memory.
Keywords: ERK; learning and memory; neurobiology ERK; learning and memory; neurobiology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Peng, S.; Zhang, Y.; Zhang, J.; Wang, H.; Ren, B. ERK in Learning and Memory: A Review of Recent Research. Int. J. Mol. Sci. 2010, 11, 222-232.

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