Int. J. Mol. Sci. 2010, 11(1), 233-253; doi:10.3390/ijms11010233
Review

A Review on the Effects of Supercritical Carbon Dioxide on Enzyme Activity

1email and 2,* email
Received: 23 November 2009; in revised form: 7 January 2010 / Accepted: 9 January 2010 / Published: 19 January 2010
(This article belongs to the Special Issue Supercritical Carbon Dioxide)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Different types of enzymes such as lipases, several phosphatases, dehydrogenases, oxidases, amylases and others are well suited for the reactions in SC-CO2. The stability and the activity of enzymes exposed to carbon dioxide under high pressure depend on enzyme species, water content in the solution and on the pressure and temperature of the reaction system. The three-dimensional structure of enzymes may be significantly altered under extreme conditions, causing their denaturation and consequent loss of activity. If the conditions are less adverse, the protein structure may be largely retained. Minor structural changes may induce an alternative active protein state with altered enzyme activity, specificity and stability.
Keywords: enzyme; supercritical carbon dioxide; synthesis; hydrolysis; inactivation
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MDPI and ACS Style

Wimmer, Z.; Zarevúcka, M. A Review on the Effects of Supercritical Carbon Dioxide on Enzyme Activity. Int. J. Mol. Sci. 2010, 11, 233-253.

AMA Style

Wimmer Z, Zarevúcka M. A Review on the Effects of Supercritical Carbon Dioxide on Enzyme Activity. International Journal of Molecular Sciences. 2010; 11(1):233-253.

Chicago/Turabian Style

Wimmer, Zdenĕk; Zarevúcka, Marie. 2010. "A Review on the Effects of Supercritical Carbon Dioxide on Enzyme Activity." Int. J. Mol. Sci. 11, no. 1: 233-253.

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