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Int. J. Mol. Sci. 2010, 11(1), 206-221; doi:10.3390/ijms11010206

Photonic Methods to Enhance Fluorescence Correlation Spectroscopy and Single Molecule Fluorescence Detection

Institut Fresnel, Aix-Marseille Université, CNRS, Ecole Centrale Marseille, Domaine Universitaire de Saint-Jérôme, 13397 Marseille cedex 20, France
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Received: 24 November 2009 / Revised: 4 January 2010 / Accepted: 8 January 2010 / Published: 13 January 2010
(This article belongs to the Special Issue Single Molecules)
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Abstract

Recent advances in nanophotonics open the way for promising applications towards efficient single molecule fluorescence analysis. In this review, we discuss how photonic methods bring innovative solutions for two essential questions: how to detect a single molecule in a highly concentrated solution, and how to enhance the faint optical signal emitted per molecule? The focus is set primarily on the widely used technique of fluorescence correlation spectroscopy (FCS), yet the discussion can be extended to other single molecule detection methods. View Full-Text
Keywords: single molecule; fluorescence correlation spectroscopy FCS; nanophotonics; biophotonics single molecule; fluorescence correlation spectroscopy FCS; nanophotonics; biophotonics
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wenger, J.; Rigneault, H. Photonic Methods to Enhance Fluorescence Correlation Spectroscopy and Single Molecule Fluorescence Detection. Int. J. Mol. Sci. 2010, 11, 206-221.

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