Int. J. Mol. Sci. 2010, 11(1), 206-221; doi:10.3390/ijms11010206
Review

Photonic Methods to Enhance Fluorescence Correlation Spectroscopy and Single Molecule Fluorescence Detection

Jérome Wenger* email and Hervé Rigneault
Institut Fresnel, Aix-Marseille Université, CNRS, Ecole Centrale Marseille, Domaine Universitaire de Saint-Jérôme, 13397 Marseille cedex 20, France
* Author to whom correspondence should be addressed.
Received: 24 November 2009; in revised form: 4 January 2010 / Accepted: 8 January 2010 / Published: 13 January 2010
(This article belongs to the Special Issue Single Molecules)
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Abstract: Recent advances in nanophotonics open the way for promising applications towards efficient single molecule fluorescence analysis. In this review, we discuss how photonic methods bring innovative solutions for two essential questions: how to detect a single molecule in a highly concentrated solution, and how to enhance the faint optical signal emitted per molecule? The focus is set primarily on the widely used technique of fluorescence correlation spectroscopy (FCS), yet the discussion can be extended to other single molecule detection methods.
Keywords: single molecule; fluorescence correlation spectroscopy FCS; nanophotonics; biophotonics

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MDPI and ACS Style

Wenger, J.; Rigneault, H. Photonic Methods to Enhance Fluorescence Correlation Spectroscopy and Single Molecule Fluorescence Detection. Int. J. Mol. Sci. 2010, 11, 206-221.

AMA Style

Wenger J, Rigneault H. Photonic Methods to Enhance Fluorescence Correlation Spectroscopy and Single Molecule Fluorescence Detection. International Journal of Molecular Sciences. 2010; 11(1):206-221.

Chicago/Turabian Style

Wenger, Jérome; Rigneault, Hervé. 2010. "Photonic Methods to Enhance Fluorescence Correlation Spectroscopy and Single Molecule Fluorescence Detection." Int. J. Mol. Sci. 11, no. 1: 206-221.

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