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• Sá, CM.
• Ramos, AA.
• Azevedo, MF.
• Lima, CF.
• Fernandes-Ferreira, M
• Pereira-Wilson, C
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• Sá, CM.
• Ramos, AA.
• Azevedo, MF.
• Lima, CF.
• Fernandes-Ferreira, M
• Pereira-Wilson, C
• [+] on PubMed
• Sá, CM.
• Ramos, AA.
• Azevedo, MF.
• Lima, CF.
• Fernandes-Ferreira, M
• Pereira-Wilson, C

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Int. J. Mol. Sci. 2009, 10(9), 3937-3950; doi:10.3390/ijms10093937

Article

Sage Tea Drinking Improves Lipid Profile and Antioxidant Defences in Humans

Carla M. Sá ¹ , Alice A. Ramos ¹ , Marisa F. Azevedo ¹ , Cristovao F. Lima ² , Manuel Fernandes-Ferreira ²  and Cristina Pereira-Wilson ^1,*

¹ CBMA–Centre of Molecular and Environmental Biology/Department of Biology, School of Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal ² CITAB–Centre for the Research and Technology of Agro-Environment and Biological Sciences/Department of Biology, School of Sciences, University of Minho, 4710-057 Braga, Portugal

* Author to whom correspondence should be addressed.

Received: 1 July 2009; in revised form: 25 August 2009 / Accepted: 8 September 2009 / Published: 9 September 2009

(This article belongs to the Special Issue Natural Compounds for the Treatment and Prevention of Metabolic Diseases)

Download PDF Full-Text [242 KB, uploaded 9 September 2009 11:34 CEST]

Abstract: Salvia officinalis (common sage) is a plant with antidiabetic properties. A pilot trial (non-randomized crossover trial) with six healthy female volunteers (aged 40-50) was designed to evaluate the beneficial properties of sage tea consumption on blood glucose regulation, lipid profile and transaminase activity in humans. Effects of sage consumption on erythrocytes’ SOD and CAT activities and on Hsp70 expression in lymphocytes were also evaluated. Four weeks sage tea treatment had no effects on plasma glucose. An improvement in lipid profile was observed with lower plasma LDL cholesterol and total cholesterol levels as well as higher plasma HDL cholesterol levels during and two weeks after treatment. Sage tea also increased lymphocyte Hsp70 expression and erythrocyte SOD and CAT activities. No hepatotoxic effects or other adverse effects were observed.

Keywords: Salvia officinalis L.; type 2 diabetes mellitus; lipid profile; human trial; antioxidant defences

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