Int. J. Mol. Sci. 2009, 10(7), 2921-2934; doi:10.3390/ijms10072921
Article

The Dimeric Proto-Ribosome: Structural Details and Possible Implications on the Origin of Life

Received: 1 June 2009; Accepted: 25 June 2009 / Published: 30 June 2009
(This article belongs to the Special Issue Origin of Life)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A symmetric pocket-like entity, composed of two L-shaped RNA units, encircles the peptide synthesis site within the contemporary ribosome. This entity was suggested to be the vestige of a dimeric proto-ribosome, which could have formed spontaneously in the prebiotic world, catalyzing non-coded peptide bond formation and elongation. This structural element, beyond offering the initial step in the evolution of translation, is hypothesized here to be linked to the origin of life. By catalyzing the production of random peptide chains, the proto-ribosome could have enabled the formation of primary enzymes, launching a process of co-evolution of the translation apparatus and the proteins, thus presenting an alternative to the RNA world hypothesis.
Keywords: proto-ribosome; origin of life; ribosome symmetrical region
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MDPI and ACS Style

Agmon, I. The Dimeric Proto-Ribosome: Structural Details and Possible Implications on the Origin of Life. Int. J. Mol. Sci. 2009, 10, 2921-2934.

AMA Style

Agmon I. The Dimeric Proto-Ribosome: Structural Details and Possible Implications on the Origin of Life. International Journal of Molecular Sciences. 2009; 10(7):2921-2934.

Chicago/Turabian Style

Agmon, Ilana. 2009. "The Dimeric Proto-Ribosome: Structural Details and Possible Implications on the Origin of Life." Int. J. Mol. Sci. 10, no. 7: 2921-2934.

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