Int. J. Mol. Sci. 2009, 10(7), 2935-2957; doi:10.3390/ijms10072935
Review

Applications of Isothermal Titration Calorimetry in Biophysical Studies of G-quadruplexes

Received: 5 June 2009; in revised form: 29 June 2009 / Accepted: 29 June 2009 / Published: 2 July 2009
(This article belongs to the Special Issue Isothermal Titration Calorimetry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: G-quadruplexes are higher-order nucleic acids structures formed by G-rich sequences that are stabilized by tetrads of hydrogen-bonded guanine bases. Recently, there has been growing interest in the study of G-quadruplexes because of their possible involvement in many biological processes. Isothermal titration calorimetry (ITC) has been proven to be a useful tool to study the energetic aspects of G-quadruplex interactions. Particularly, ITC has been applied many times to determine the thermodynamic properties of drug-quadruplex interactions to screening among various drugs and to address drug design. In the present review, we will focus on the ITC studies of G-quadruplex structures and their interaction with proteins and drugs and the most significant results will be discussed.
Keywords: G-quadruplex; isothermal titration calorimetry; thermodynamic; drug
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MDPI and ACS Style

Pagano, B.; Mattia, C.A.; Giancola, C. Applications of Isothermal Titration Calorimetry in Biophysical Studies of G-quadruplexes. Int. J. Mol. Sci. 2009, 10, 2935-2957.

AMA Style

Pagano B, Mattia CA, Giancola C. Applications of Isothermal Titration Calorimetry in Biophysical Studies of G-quadruplexes. International Journal of Molecular Sciences. 2009; 10(7):2935-2957.

Chicago/Turabian Style

Pagano, Bruno; Mattia, Carlo Andrea; Giancola, Concetta. 2009. "Applications of Isothermal Titration Calorimetry in Biophysical Studies of G-quadruplexes." Int. J. Mol. Sci. 10, no. 7: 2935-2957.

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