Int. J. Mol. Sci. 2009, 10(7), 2935-2957; doi:10.3390/ijms10072935
Review

Applications of Isothermal Titration Calorimetry in Biophysical Studies of G-quadruplexes

1 Dipartimento di Scienze Farmaceutiche, Università di Salerno, Via Ponte Don Melillo, 84084, Fisciano (SA), Italy 2 Dipartimento di Chimica, Università di Napoli Federico II, via Cintia, 80126, Napoli, Italy
* Authors to whom correspondence should be addressed.
Received: 5 June 2009; in revised form: 29 June 2009 / Accepted: 29 June 2009 / Published: 2 July 2009
(This article belongs to the Special Issue Isothermal Titration Calorimetry)
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Abstract: G-quadruplexes are higher-order nucleic acids structures formed by G-rich sequences that are stabilized by tetrads of hydrogen-bonded guanine bases. Recently, there has been growing interest in the study of G-quadruplexes because of their possible involvement in many biological processes. Isothermal titration calorimetry (ITC) has been proven to be a useful tool to study the energetic aspects of G-quadruplex interactions. Particularly, ITC has been applied many times to determine the thermodynamic properties of drug-quadruplex interactions to screening among various drugs and to address drug design. In the present review, we will focus on the ITC studies of G-quadruplex structures and their interaction with proteins and drugs and the most significant results will be discussed.
Keywords: G-quadruplex; isothermal titration calorimetry; thermodynamic; drug

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MDPI and ACS Style

Pagano, B.; Mattia, C.A.; Giancola, C. Applications of Isothermal Titration Calorimetry in Biophysical Studies of G-quadruplexes. Int. J. Mol. Sci. 2009, 10, 2935-2957.

AMA Style

Pagano B, Mattia CA, Giancola C. Applications of Isothermal Titration Calorimetry in Biophysical Studies of G-quadruplexes. International Journal of Molecular Sciences. 2009; 10(7):2935-2957.

Chicago/Turabian Style

Pagano, Bruno; Mattia, Carlo Andrea; Giancola, Concetta. 2009. "Applications of Isothermal Titration Calorimetry in Biophysical Studies of G-quadruplexes." Int. J. Mol. Sci. 10, no. 7: 2935-2957.

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