Next Article in Journal
Characterization and Purification of Polydisperse Reconstituted Lipoproteins and Nanolipoprotein Particles
Next Article in Special Issue
Isothermal Microcalorimetry to Investigate Non Specific Interactions in Biophysical Chemistry
Previous Article in Journal
The Dimeric Proto-Ribosome: Structural Details and Possible Implications on the Origin of Life
Previous Article in Special Issue
Heats of Mixing Using an Isothermal Titration Calorimeter: Associated Thermal Effects
Int. J. Mol. Sci. 2009, 10(7), 2935-2957; doi:10.3390/ijms10072935
Review

Applications of Isothermal Titration Calorimetry in Biophysical Studies of G-quadruplexes

1,* , 1
 and
2,*
Received: 5 June 2009 / Revised: 29 June 2009 / Accepted: 29 June 2009 / Published: 2 July 2009
(This article belongs to the Special Issue Isothermal Titration Calorimetry)
View Full-Text   |   Download PDF [251 KB, uploaded 19 June 2014]   |   Browse Figures

Abstract

G-quadruplexes are higher-order nucleic acids structures formed by G-rich sequences that are stabilized by tetrads of hydrogen-bonded guanine bases. Recently, there has been growing interest in the study of G-quadruplexes because of their possible involvement in many biological processes. Isothermal titration calorimetry (ITC) has been proven to be a useful tool to study the energetic aspects of G-quadruplex interactions. Particularly, ITC has been applied many times to determine the thermodynamic properties of drug-quadruplex interactions to screening among various drugs and to address drug design. In the present review, we will focus on the ITC studies of G-quadruplex structures and their interaction with proteins and drugs and the most significant results will be discussed.
Keywords: G-quadruplex; isothermal titration calorimetry; thermodynamic; drug G-quadruplex; isothermal titration calorimetry; thermodynamic; drug
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Pagano, B.; Mattia, C.A.; Giancola, C. Applications of Isothermal Titration Calorimetry in Biophysical Studies of G-quadruplexes. Int. J. Mol. Sci. 2009, 10, 2935-2957.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert