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Int. J. Mol. Sci. 2009, 10(4), 1609-1627; doi:10.3390/ijms10041609

Neuronal Aneuploidy in Health and Disease:A Cytomic Approach to Understand the Molecular Individuality of Neurons

Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany
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Present address: Forschungszentrum Dresden-Rossendorf, Institute of Radiopharmacy, Dresden, Germany
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Author to whom correspondence should be addressed.
Received: 24 February 2009 / Revised: 7 April 2009 / Accepted: 9 April 2009 / Published: 15 March 2009
(This article belongs to the Special Issue Advances in Molecular Neuropathology)
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Abstract

Structural variation in the human genome is likely to be an important mechanism for neuronal diversity and brain disease. A combination of multiple different forms of aneuploid cells due to loss or gain of whole chromosomes giving rise to cellular diversity at the genomic level have been described in neurons of the normal and diseased adult human brain. Here, we describe recent advances in molecular neuropathology based on the combination of slide-based cytometry with molecular biological techniques that will contribute to the understanding of genetic neuronal heterogeneity in the CNS and its potential impact on Alzheimer´s disease and age-related disorders. View Full-Text
Keywords: Alu-repeats; Alzheimer´s disease; cell cycle; cell death; chromosomal mosaicism; in situ hybridisation; laser capture microdissection; neurodegeneration; slide-based cytometry Alu-repeats; Alzheimer´s disease; cell cycle; cell death; chromosomal mosaicism; in situ hybridisation; laser capture microdissection; neurodegeneration; slide-based cytometry
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Arendt, T.; Mosch, B.; Morawski, M. Neuronal Aneuploidy in Health and Disease:A Cytomic Approach to Understand the Molecular Individuality of Neurons. Int. J. Mol. Sci. 2009, 10, 1609-1627.

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