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Molecular Neuropathology of Gliomas
Department of Neuropathology, Heinrich-Heine-University, Moorenstr. 5, 40225 Duesseldorf, Germany
* Author to whom correspondence should be addressed.
Received: 9 December 2008; in revised form: 2 January 2009 / Accepted: 5 January 2009 / Published: 7 January 2009
Abstract: Gliomas are the most common primary human brain tumors. They comprise a heterogeneous group of benign and malignant neoplasms that are histologically classified according to the World Health Organization (WHO) classification of tumors of the nervous system. Over the past 20 years the cytogenetic and molecular genetic alterations associated with glioma formation and progression have been intensely studied and genetic profiles as additional aids to the definition of brain tumors have been incorporated in the WHO classification. In fact, first steps have been undertaken in supplementing classical histopathological diagnosis by the use of molecular tests, such as MGMT promoter hypermethylation in glioblastomas or detection of losses of chromosome arms 1p and 19q in oligodendroglial tumors. The tremendous progress that has been made in the use of array-based profiling techniques will likely contribute to a further molecular refinement of glioma classification and lead to the identification of glioma core pathways that can be specifically targeted by more individualized glioma therapies.
Keywords: Glioblastoma; oligodendroglioma; ependymoma; molecular diagnostics; genetics; MGMT; 1p; 19q; biomarker; profiling
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Riemenschneider, M.J.; Reifenberger, G. Molecular Neuropathology of Gliomas. Int. J. Mol. Sci. 2009, 10, 184-212.
Riemenschneider MJ, Reifenberger G. Molecular Neuropathology of Gliomas. International Journal of Molecular Sciences. 2009; 10(1):184-212.
Riemenschneider, Markus J.; Reifenberger, Guido. 2009. "Molecular Neuropathology of Gliomas." Int. J. Mol. Sci. 10, no. 1: 184-212.