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Fluorescence Studies of Selected 2-Alkylaminopyrimidines
Department of Chemistry, Faculty of Science, Univ. of Malaya, 50603, Kuala Lumpur, Malaysia
Department of Chemical Sciences, Kolej Universiti Sains dan Teknologi, Mengabang Telipot, 21030 Kuala Terengganu, Terengganu, Malaysia
Lot 15, Jalan 1B, Kg. Cheras Baru, 56100, Kuala Lumpur, Malaysia
* Author to whom correspondence should be addressed.
Received: 2 March 2004; Accepted: 15 March 2004 / Published: 30 June 2004
Abstract: The reactions of 2-chloropyrimidine with methylamine, ethylamine and piperidine gave the corresponding 2-N-methylamino-, 2-N-ethylamino- and 2N- piperidinopyrimidines, respectively. The fluorescence properties of these alkylamino derivatives in chloroform, ethyl acetate, carbon tetrachloride, acetone, ether, ethanol and methanol were studied. All the alkylamino derivatives showed the highest fluorescence intensity in polar protic solvents; thus 2-N-methylaminopyrimidine (highest fluorescence intensity at 377 nm when excited at 282 nm) and 2-N-ethylaminopyrimidine (highest fluorescence intensity at 375 nm, when excited at 286 nm) showed the highest fluorescence in methanol. In ethanol, 2-N-piperidinopyrimidine showed a fluorescence peak at 403 nm when excited at 360 nm and in chloroform it fluoresced at 392 nm when excited at 356 nm.
Keywords: Fluorescence spectroscopy; alkylaminopyrimidines; fluorometry; fluorogenic reagents
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Abdullah, Z.; Tahir, N.M.; Abas, M.R.; Aiyub, Z.; Low, B.K. Fluorescence Studies of Selected 2-Alkylaminopyrimidines. Molecules 2004, 9, 520-526.
Abdullah Z, Tahir NM, Abas MR, Aiyub Z, Low BK. Fluorescence Studies of Selected 2-Alkylaminopyrimidines. Molecules. 2004; 9(7):520-526.
Abdullah, Z.; Tahir, N. M.; Abas, M. R.; Aiyub, Z.; Low, B. K. 2004. "Fluorescence Studies of Selected 2-Alkylaminopyrimidines." Molecules 9, no. 7: 520-526.