Synthesis and Characterisation of Macrocyclic Diamino Chiral Crown Ethers

doi:10.3390/90600513

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Molecules 2004, 9(6), 513-519; doi:10.3390/90600513

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Synthesis and Characterisation of Macrocyclic Diamino Chiral Crown Ethers

Waldo H. Correa * and Janet L. Scott

Centre for Green Chemistry, Monash University, P.O. Box 23, Victoria, 3800, Australia

* Author to whom correspondence should be addressed.

Received: 4 March 2004 / Accepted: 10 March 2004 / Published: 31 May 2004

(This article belongs to the Special Issue RACI 2003 symposium)

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Abstract: A benign and efficient synthesis of chiral macrocyclic ‘aza-crown’ ethers of varying ring size is reported. The synthesis involves a Schiff base condensation of ether linked dialdehydes of varying chain length and (1R,2R)-(–)-1,2-diaminocyclohexane under mild conditions to yield the macrocycles, which are subsequently reduced to yield the diamino analogues.

Keywords: Chiral diamino macrocycles; ether linked dialdehydes

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Cite This Article

MDPI and ACS Style

Correa, W.H.; Scott, J.L. Synthesis and Characterisation of Macrocyclic Diamino Chiral Crown Ethers. Molecules 2004, 9, 513-519.

AMA Style

Correa W.H., Scott J.L. Synthesis and Characterisation of Macrocyclic Diamino Chiral Crown Ethers. Molecules. 2004; 9(6):513-519.

Chicago/Turabian Style

Correa, Waldo H.; Scott, Janet L. 2004. "Synthesis and Characterisation of Macrocyclic Diamino Chiral Crown Ethers." Molecules 9, no. 6: 513-519.

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