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Molecules 2004, 9(3), 164-169; doi:10.3390/90300164
Article

Phenoxydifluoromethyl Substituted Nitrogen Heterocycles. Synthesis and Heterocyclization Reactions of Ethyl 4,4-Difluoro- 4-phenoxyacetoacetate

, ,  and *
A. N. Nesmeyanov Institute of Organoelement Compounds (INEOS), Russian Academy of Sciences, Vavilov Str. 28, 119991 Moscow, Russia
* Author to whom correspondence should be addressed.
Received: 15 January 2004 / Accepted: 18 January 2004 / Published: 28 February 2004
(This article belongs to the Special Issue Biologically Relevant Heterocyclic Compounds)
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Abstract

Ethyl 4,4-difluoro-4-phenoxyacetoacetate was obtained and studied as a precursor to new heterocyclic compounds. 6-Hydroxypyrimidine, 1,3-dihydro-1,5- benzodiazepin-2-one, quinolin-2-one and 6-hydroxypyrazolo[3,4-b]pyridine derivatives containing phenoxydifluoromethyl groups were synthesized. These results make it possible to introduce aryloxydifluoromethyl substituents for the design of biologically active heterocycles.
Keywords: Ethyl 4; 4-difluoro-4-phenoxyacetoacetate; heterocyclization reactions; phenoxydifluoromethyl group; biologically active heterocycles. Ethyl 4; 4-difluoro-4-phenoxyacetoacetate; heterocyclization reactions; phenoxydifluoromethyl group; biologically active heterocycles.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Solodukhin, S.Y.; Peregudov, A.S.; Vorontsov, E.V.; Chkanikov, N.D. Phenoxydifluoromethyl Substituted Nitrogen Heterocycles. Synthesis and Heterocyclization Reactions of Ethyl 4,4-Difluoro- 4-phenoxyacetoacetate. Molecules 2004, 9, 164-169.

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