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Molecules 2004, 9(3), 164-169; doi:10.3390/90300164

Phenoxydifluoromethyl Substituted Nitrogen Heterocycles. Synthesis and Heterocyclization Reactions of Ethyl 4,4-Difluoro- 4-phenoxyacetoacetate

A. N. Nesmeyanov Institute of Organoelement Compounds (INEOS), Russian Academy of Sciences, Vavilov Str. 28, 119991 Moscow, Russia
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Received: 15 January 2004 / Accepted: 18 January 2004 / Published: 28 February 2004
(This article belongs to the Special Issue Biologically Relevant Heterocyclic Compounds)
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Abstract

Ethyl 4,4-difluoro-4-phenoxyacetoacetate was obtained and studied as a precursor to new heterocyclic compounds. 6-Hydroxypyrimidine, 1,3-dihydro-1,5- benzodiazepin-2-one, quinolin-2-one and 6-hydroxypyrazolo[3,4-b]pyridine derivatives containing phenoxydifluoromethyl groups were synthesized. These results make it possible to introduce aryloxydifluoromethyl substituents for the design of biologically active heterocycles. View Full-Text
Keywords: Ethyl 4; 4-difluoro-4-phenoxyacetoacetate; heterocyclization reactions; phenoxydifluoromethyl group; biologically active heterocycles. Ethyl 4; 4-difluoro-4-phenoxyacetoacetate; heterocyclization reactions; phenoxydifluoromethyl group; biologically active heterocycles.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Solodukhin, S.Y.; Peregudov, A.S.; Vorontsov, E.V.; Chkanikov, N.D. Phenoxydifluoromethyl Substituted Nitrogen Heterocycles. Synthesis and Heterocyclization Reactions of Ethyl 4,4-Difluoro- 4-phenoxyacetoacetate. Molecules 2004, 9, 164-169.

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