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Molecules 2004, 9(3), 158-163; doi:10.3390/90300158

The Synthesis of Dicationic Extended Bis-Benzimidazoles

1, 2 and 1,*
1 Department of Chemistry Georgia State University, Atlanta, Georgia 30303, USA 2 Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama 36849, USA
* Author to whom correspondence should be addressed.
Received: 17 January 2004 / Revised: 26 January 2004 / Accepted: 27 January 2004 / Published: 28 February 2004
(This article belongs to the Special Issue Biologically Relevant Heterocyclic Compounds)
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The synthesis of extended dicationic bis-benzimidazoles starting from trans-1,2-bis(4-cyanophenyl)ethene and trans-1,2-bis(4-cyanophenyl)cyclopropane is reported. The target diamidines show significant in vitro activity against B. subtilis.
Keywords: DIBAL reduction; benzimidazoles; amidines; Bacillus subtilis. DIBAL reduction; benzimidazoles; amidines; Bacillus subtilis.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kang, Z.; Dykstra, C.C.; Boykin, D.W. The Synthesis of Dicationic Extended Bis-Benzimidazoles. Molecules 2004, 9, 158-163.

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