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Molecules 2004, 9(10), 842-848; doi:10.3390/91000842

A Novel Approach to the Synthesis of 6-Amino-7-hydroxy-flavone

1, 1,* , 1, 2, 1 and 1
Received: 8 May 2004 / Accepted: 8 July 2004 / Published: 30 September 2004
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Abstract: A novel approach to the synthesis of 6-amino-7-hydroxyflavone (1) is described. Reaction in acetone of 2′,4′-dihydroxy-5′-nitroacetophenone and benzoyl chloride in the presence of potassium carbonate affords 3-benzoyl-7-hydroxy-6-nitroflavone, which is cleaved in 5% ethanolic potassium hydroxide to give 1-(2,4-dihydroxy-5-nitrophenyl)-3- phenyl-1,3-propanedione. The 1,3-diketone thus formed is then transformed into 7-hydroxy- 6-nitroflavone, followed by reduction to afford the title compound.
Keywords: Flavones; 4H-1-benzopyan-4-one; aminoflavones; chromones Flavones; 4H-1-benzopyan-4-one; aminoflavones; chromones
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Tang, L.; Zhang, S.; Yang, J.; Gao, W.; Cui, J.; Zhuang, T. A Novel Approach to the Synthesis of 6-Amino-7-hydroxy-flavone. Molecules 2004, 9, 842-848.

AMA Style

Tang L, Zhang S, Yang J, Gao W, Cui J, Zhuang T. A Novel Approach to the Synthesis of 6-Amino-7-hydroxy-flavone. Molecules. 2004; 9(10):842-848.

Chicago/Turabian Style

Tang, Lijun; Zhang, Shufen; Yang, Jinzong; Gao, Wentao; Cui, Jian; Zhuang, Tianyu. 2004. "A Novel Approach to the Synthesis of 6-Amino-7-hydroxy-flavone." Molecules 9, no. 10: 842-848.

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