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Molecules 2004, 9(10), 849-859; https://doi.org/10.3390/91000849

Unexpected Hydrazinolysis Behaviour of 1-Chloro-4-methyl-5H-pyridazino[4,5-b]indole and a Convenient Synthesis of New [1,2,4]-Triazolo[4’,3’:1,6]pyridazino[4,5-b]indoles

1
Chemistry Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt
2
Department of Pharmaceutical Chemistry, University of Vienna, Althanstraße 14, A-1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
Received: 8 June 2004 / Accepted: 18 June 2004 / Published: 30 September 2004
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Abstract

Reaction of the title compound with hydrazine in the presence of air gives the 1-unsubstituted parent system via oxidative dehydrazination of the 1-hydrazino intermediate. The latter can be obtained in high yield by carrying out the hydrazinolysis step under inert gas, and it is smoothly converted into [1,2,4]-triazolo[4’,3’:1,6]pyridazino[4,5- b]indoles. View Full-Text
Keywords: Oxidative dehydrazination; pyridazine; indole; triazole. Oxidative dehydrazination; pyridazine; indole; triazole.
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El-Kashef, H.; Farghaly, A.A.H.; Haider, N.; Wobus, A. Unexpected Hydrazinolysis Behaviour of 1-Chloro-4-methyl-5H-pyridazino[4,5-b]indole and a Convenient Synthesis of New [1,2,4]-Triazolo[4’,3’:1,6]pyridazino[4,5-b]indoles. Molecules 2004, 9, 849-859.

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