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Molecules 2004, 9(10), 815-824; doi:10.3390/91000815

Synthesis of Novel Azo Schiff Bases and Their Antibacterial and Antifungal Activities

1
Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran
2
Department of Bacteriology and Virology, Shiraz Medical School, Shiraz University Medical Science, Shiraz 71345, Iran
3
Department of Parasitology and Mycology, Shiraz Medical School, Shiraz University Medical Science, Shiraz 71345, Iran
*
Author to whom correspondence should be addressed.
Received: 19 January 2004 / Accepted: 26 February 2004 / Published: 30 September 2004
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Abstract

Ten new azo Schiff bases 5a-h and 7a-b were prepared in excellent yields via the condensation of different aromatic amines and a new azoaldehyde, 2-hydroxy-3- methoxy-5-(4-methoxyphenylazo)benzaldehyde (4) by two different methods. All new compounds were tested against five microorganisms: Staphylococcus aureus (Gram positive and methicillin resistant), Bacillus subtilis (Gram positive), Kelebsiella pneumonia, Pseudomonas aeruginosa and Escherichia coli (all Gram negative). Compounds 4, 5a, 5c, 5d and 5g were moderately active against Staphylococcus aureus and Bacillus subtilis. Compound 7b was highly active against Bacillus subtilis and moderately active against Staphylococcus aureus. Other compounds were inactive against these strains of bacteria. The antifungal activities of these compounds were also tested against eight different fungal species. None of them were active against the fungi species tested. View Full-Text
Keywords: Schiff bases; azo compounds; antibacterial and antifungal activity; o-vanillin Schiff bases; azo compounds; antibacterial and antifungal activity; o-vanillin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Jarrahpour, A.A.; Motamedifar, M.; Pakshir, K.; Hadi, N.; Zarei, M. Synthesis of Novel Azo Schiff Bases and Their Antibacterial and Antifungal Activities. Molecules 2004, 9, 815-824.

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