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Molecules 2003, 8(6), 488-499; doi:10.3390/80600488

Novel Heteroatom-containing Vitamin D3 Analogs: Efficient Synthesis of 1α,25-Dihydroxyvitamin D3-26,23-lactam

Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
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Received: 13 May 2003 / Revised: 20 May 2003 / Accepted: 21 May 2003 / Published: 30 June 2003
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Abstract

Vitamin D3 and its synthetic analogs are promising compounds for controlling various types of cell differentiation. In this article, we describe the synthesis of novel vitamin D3 analogs containing heteroatoms in their side chains – so-called vitamin D3 lactam analogs – via 1,3-dipolar cycloaddition reaction as a key step.
Keywords: Vitamin D3; Vitamin D3 analog; lactam; 1; 3-dipolar cycloaddition reaction Vitamin D3; Vitamin D3 analog; lactam; 1; 3-dipolar cycloaddition reaction
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kato, Y.; Hashimoto, Y.; Nagasawa, K. Novel Heteroatom-containing Vitamin D3 Analogs: Efficient Synthesis of 1α,25-Dihydroxyvitamin D3-26,23-lactam. Molecules 2003, 8, 488-499.

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