Molecules 2003, 8(6), 488-499; doi:10.3390/80600488
Article

Novel Heteroatom-containing Vitamin D3 Analogs: Efficient Synthesis of 1α,25-Dihydroxyvitamin D3-26,23-lactam

Yuko Kato, Yuichi Hashimoto and Kazuo Nagasawa* email
Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
* Author to whom correspondence should be addressed.
Received: 13 May 2003; in revised form: 20 May 2003 / Accepted: 21 May 2003 / Published: 30 June 2003
(This article belongs to the Special Issue Selected Papers from the Second Eurasian Meeting on Heterocyclic Chemistry: Heterocycles in Organic and Combinatorial Chemistry)
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Abstract: Vitamin D3 and its synthetic analogs are promising compounds for controlling various types of cell differentiation. In this article, we describe the synthesis of novel vitamin D3 analogs containing heteroatoms in their side chains – so-called vitamin D3 lactam analogs – via 1,3-dipolar cycloaddition reaction as a key step.
Keywords: Vitamin D3; Vitamin D3 analog; lactam; 1; 3-dipolar cycloaddition reaction

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Cite This Article

MDPI and ACS Style

Kato, Y.; Hashimoto, Y.; Nagasawa, K. Novel Heteroatom-containing Vitamin D3 Analogs: Efficient Synthesis of 1α,25-Dihydroxyvitamin D3-26,23-lactam. Molecules 2003, 8, 488-499.

AMA Style

Kato Y, Hashimoto Y, Nagasawa K. Novel Heteroatom-containing Vitamin D3 Analogs: Efficient Synthesis of 1α,25-Dihydroxyvitamin D3-26,23-lactam. Molecules. 2003; 8(6):488-499.

Chicago/Turabian Style

Kato, Yuko; Hashimoto, Yuichi; Nagasawa, Kazuo. 2003. "Novel Heteroatom-containing Vitamin D3 Analogs: Efficient Synthesis of 1α,25-Dihydroxyvitamin D3-26,23-lactam." Molecules 8, no. 6: 488-499.

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