Molecules 2003, 8(6), 500-504; doi:10.3390/80600500

The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one

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Received: 13 May 2003; Accepted: 15 May 2003 / Published: 30 June 2003
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: 3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4,5-disubstituted pyrimidines and functionalized 4-aminopyridines. It also behaves like α-nitro-formylacetic acid to give 5,6-disubstituted 3-nitro-2-pyridones.
Keywords: Nitropyrimidinone; ring transformation; pyridone; pyrimidine; aminopyridine
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MDPI and ACS Style

Nishiwaki, N.; Tamura, M.; Hori, K.; Tohda, Y.; Ariga, M. The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one. Molecules 2003, 8, 500-504.

AMA Style

Nishiwaki N, Tamura M, Hori K, Tohda Y, Ariga M. The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one. Molecules. 2003; 8(6):500-504.

Chicago/Turabian Style

Nishiwaki, Nagatoshi; Tamura, Mina; Hori, Kazushige; Tohda, Yasuo; Ariga, Masahiro. 2003. "The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one." Molecules 8, no. 6: 500-504.

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