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Molecules 2003, 8(6), 500-504; doi:10.3390/80600500

The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one

Department of Chemistry, Osaka Kyoiku University, Asahigaoka, Kashiwara, Osaka 582-8582, Japan
Authors to whom correspondence should be addressed.
Received: 13 May 2003 / Accepted: 15 May 2003 / Published: 30 June 2003
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3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4,5-disubstituted pyrimidines and functionalized 4-aminopyridines. It also behaves like α-nitro-formylacetic acid to give 5,6-disubstituted 3-nitro-2-pyridones.
Keywords: Nitropyrimidinone; ring transformation; pyridone; pyrimidine; aminopyridine Nitropyrimidinone; ring transformation; pyridone; pyrimidine; aminopyridine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Nishiwaki, N.; Tamura, M.; Hori, K.; Tohda, Y.; Ariga, M. The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one. Molecules 2003, 8, 500-504.

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