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Molecules 2003, 8(2), 287-296; doi:10.3390/80200287
Article

Synthesis, Crystal Structure, Stacking Effect and Antibacterial Studies of a Novel Quaternary Copper (II) Complex with Quinolone

1, 2,* , 3 and 2
Received: 1 January 2003; Published: 28 February 2003
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Abstract: The structural properties of a new copper (II) complex [Cu2(cip)2(bpy)2(pip)]·6H2O (bpy=2,2’-bipyridyl, cip=1-cyclopropyl-6-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, pip= piperazinyl anion), obtained during the synthesis of the copper complex with ciprofloxacin (cpf), has been investigated. The complex crystallizes in the triclinic system, space group P-1. The cell dimensions are: a=6.874(2) Å, b= 10.761(3) Å, c= 17.969(5) Å, α =80.071(6)°, β= 85.253(6)°, γ=79.109(6)°,V=1284.5(6) Å3, and Z=2. The Cu (II) ion displays a five-coordinate square pyramidal coordination with two nitrogen donors from bpy, the 4-keto and 3-carboxylate oxygen donors of cip, and the third nitrogen atom of the pip anion occupying the fifth site. There is a stack effect between cip ring and bpy ring from another molecule, where the stacking distance is about 3.5 Å. The results of elemental analysis and FT-IR measurement are also included. Both ligand and complex were assayed against gram-positive and gram-negative bacteria by the doubling dilutions method. The complex shows the same minimal inhibitory concentration (MIC) against S. Aureus and E. Coli bacteria as the corresponding ligand.
Keywords: Synthesis; crystal structure; stacking effect; antibacterial activity; copper complex; quinolone; ciprofloxacin; FT-IR Spectroscopy Synthesis; crystal structure; stacking effect; antibacterial activity; copper complex; quinolone; ciprofloxacin; FT-IR Spectroscopy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wu, G.; Wang, G.; Fu, X.; Zhu, L. Synthesis, Crystal Structure, Stacking Effect and Antibacterial Studies of a Novel Quaternary Copper (II) Complex with Quinolone. Molecules 2003, 8, 287-296.

AMA Style

Wu G, Wang G, Fu X, Zhu L. Synthesis, Crystal Structure, Stacking Effect and Antibacterial Studies of a Novel Quaternary Copper (II) Complex with Quinolone. Molecules. 2003; 8(2):287-296.

Chicago/Turabian Style

Wu, Guangguo; Wang, Guoping; Fu, Xuchun; Zhu, Longguan. 2003. "Synthesis, Crystal Structure, Stacking Effect and Antibacterial Studies of a Novel Quaternary Copper (II) Complex with Quinolone." Molecules 8, no. 2: 287-296.



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