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Molecules 2003, 8(2), 287-296; doi:10.3390/80200287
Article

Synthesis, Crystal Structure, Stacking Effect and Antibacterial Studies of a Novel Quaternary Copper (II) Complex with Quinolone

1, 2,* , 3 and 2
1 Department of Chemistry, Shantou University, Shantou 515063, P.R.China 2 Department of Chemistry, Zhejiang University, Hangzhou 310027, P.R.China 3 Department of Pharmacy, Zhejiang University City College, Hangzhou 310015, P.R.China
* Author to whom correspondence should be addressed.
Received: 1 January 2003 / Published: 28 February 2003
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Abstract

The structural properties of a new copper (II) complex [Cu2(cip)2(bpy)2(pip)]·6H2O (bpy=2,2’-bipyridyl, cip=1-cyclopropyl-6-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, pip= piperazinyl anion), obtained during the synthesis of the copper complex with ciprofloxacin (cpf), has been investigated. The complex crystallizes in the triclinic system, space group P-1. The cell dimensions are: a=6.874(2) Å, b= 10.761(3) Å, c= 17.969(5) Å, α =80.071(6)°, β= 85.253(6)°, γ=79.109(6)°,V=1284.5(6) Å3, and Z=2. The Cu (II) ion displays a five-coordinate square pyramidal coordination with two nitrogen donors from bpy, the 4-keto and 3-carboxylate oxygen donors of cip, and the third nitrogen atom of the pip anion occupying the fifth site. There is a stack effect between cip ring and bpy ring from another molecule, where the stacking distance is about 3.5 Å. The results of elemental analysis and FT-IR measurement are also included. Both ligand and complex were assayed against gram-positive and gram-negative bacteria by the doubling dilutions method. The complex shows the same minimal inhibitory concentration (MIC) against S. Aureus and E. Coli bacteria as the corresponding ligand.
Keywords: Synthesis; crystal structure; stacking effect; antibacterial activity; copper complex; quinolone; ciprofloxacin; FT-IR Spectroscopy Synthesis; crystal structure; stacking effect; antibacterial activity; copper complex; quinolone; ciprofloxacin; FT-IR Spectroscopy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Wu, G.; Wang, G.; Fu, X.; Zhu, L. Synthesis, Crystal Structure, Stacking Effect and Antibacterial Studies of a Novel Quaternary Copper (II) Complex with Quinolone. Molecules 2003, 8, 287-296.

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