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Molecules 2003, 8(2), 275-286; doi:10.3390/80200275

Synthesis and Biological Evaluation of Some New Coumarin Derivatives

1
Chemistry Department, College of Science, King Khalid University, Abha, P.O.Box 9059, Kingdom of Saudi Arabia
2
Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt
*
Author to whom correspondence should be addressed.
Received: 21 September 2002 / Revised: 12 January 2003 / Accepted: 15 February 2003 / Published: 28 February 2003
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Abstract

Pyrimidino[5`,4`-6,5]-,pyridino[3`,2`-6,5]- and pyrrolo[3`,2`-5,6]4H-pyrano-[3,2-c][1]benzopyran-6-one derivatives (5-7 and 10) could be obtained via reaction of 2-amino-4-(p-bromophenyl)-3-cyano(carboethoxy)-4H,5H-pyrano[3,2-c][1]benzopyran-5-ones (3a,b) with a variety of reagents. Alkylation of (3b) with either 2-furoyl chloride or chloroacetyl chloride gave the 2-N-substituted derivatives (9a,b). Benzofurano[3,2-b]4H-pyran derivative (12) was also prepared. The antimicrobial activity of the prepared compounds was tested. View Full-Text
Keywords: Pyrano[3; 2-c][1]benzopyran ; pyrimidino[5`; 4`-6; 5]-; pyrrolo[3`; 2`-5; 6]4Hpyrano[ 3; 2-c][1]benzopyran-6-one; antimicrobial activities Pyrano[3; 2-c][1]benzopyran ; pyrimidino[5`; 4`-6; 5]-; pyrrolo[3`; 2`-5; 6]4Hpyrano[ 3; 2-c][1]benzopyran-6-one; antimicrobial activities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Al-Haiza, M.A.; Mostafa, M.S.; El-Kady, M.Y. Synthesis and Biological Evaluation of Some New Coumarin Derivatives. Molecules 2003, 8, 275-286.

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