Molecules 2003, 8(2), 275-286; doi:10.3390/80200275
Article

Synthesis and Biological Evaluation of Some New Coumarin Derivatives

1,* email, 1 and 2
Received: 21 September 2002; in revised form: 12 January 2003 / Accepted: 15 February 2003 / Published: 28 February 2003
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Pyrimidino[5`,4`-6,5]-,pyridino[3`,2`-6,5]- and pyrrolo[3`,2`-5,6]4H-pyrano-[3,2-c][1]benzopyran-6-one derivatives (5-7 and 10) could be obtained via reaction of 2-amino-4-(p-bromophenyl)-3-cyano(carboethoxy)-4H,5H-pyrano[3,2-c][1]benzopyran-5-ones (3a,b) with a variety of reagents. Alkylation of (3b) with either 2-furoyl chloride or chloroacetyl chloride gave the 2-N-substituted derivatives (9a,b). Benzofurano[3,2-b]4H-pyran derivative (12) was also prepared. The antimicrobial activity of the prepared compounds was tested.
Keywords: Pyrano[3; 2-c][1]benzopyran ; pyrimidino[5`; 4`-6; 5]-; pyrrolo[3`; 2`-5; 6]4Hpyrano[ 3; 2-c][1]benzopyran-6-one; antimicrobial activities
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MDPI and ACS Style

Al-Haiza, M.A.; Mostafa, M.S.; El-Kady, M.Y. Synthesis and Biological Evaluation of Some New Coumarin Derivatives. Molecules 2003, 8, 275-286.

AMA Style

Al-Haiza MA, Mostafa MS, El-Kady MY. Synthesis and Biological Evaluation of Some New Coumarin Derivatives. Molecules. 2003; 8(2):275-286.

Chicago/Turabian Style

Al-Haiza, M. A.; Mostafa, M. S.; El-Kady, M. Y. 2003. "Synthesis and Biological Evaluation of Some New Coumarin Derivatives." Molecules 8, no. 2: 275-286.

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