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Synthesis and Biological Evaluation of Some New Coumarin Derivatives
Chemistry Department, College of Science, King Khalid University, Abha, P.O.Box 9059, Kingdom of Saudi Arabia
Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt
* Author to whom correspondence should be addressed.
Received: 21 September 2002; in revised form: 12 January 2003 / Accepted: 15 February 2003 / Published: 28 February 2003
Abstract: Pyrimidino[5`,4`-6,5]-,pyridino[3`,2`-6,5]- and pyrrolo[3`,2`-5,6]4H-pyrano-[3,2-c]benzopyran-6-one derivatives (5-7 and 10) could be obtained via reaction of 2-amino-4-(p-bromophenyl)-3-cyano(carboethoxy)-4H,5H-pyrano[3,2-c]benzopyran-5-ones (3a,b) with a variety of reagents. Alkylation of (3b) with either 2-furoyl chloride or chloroacetyl chloride gave the 2-N-substituted derivatives (9a,b). Benzofurano[3,2-b]4H-pyran derivative (12) was also prepared. The antimicrobial activity of the prepared compounds was tested.
Keywords: Pyrano[3; 2-c]benzopyran ; pyrimidino[5`; 4`-6; 5]-; pyrrolo[3`; 2`-5; 6]4Hpyrano[ 3; 2-c]benzopyran-6-one; antimicrobial activities
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MDPI and ACS Style
Al-Haiza, M.A.; Mostafa, M.S.; El-Kady, M.Y. Synthesis and Biological Evaluation of Some New Coumarin Derivatives. Molecules 2003, 8, 275-286.
Al-Haiza MA, Mostafa MS, El-Kady MY. Synthesis and Biological Evaluation of Some New Coumarin Derivatives. Molecules. 2003; 8(2):275-286.
Al-Haiza, M. A.; Mostafa, M. S.; El-Kady, M. Y. 2003. "Synthesis and Biological Evaluation of Some New Coumarin Derivatives." Molecules 8, no. 2: 275-286.