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• Al-Haiza, MA.
• Mostafa, MS.
• El-Kady, MY.
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• Al-Haiza, MA.
• Mostafa, MS.
• El-Kady, MY.
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• Al-Haiza, MA.
• Mostafa, MS.
• El-Kady, MY.

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Molecules 2003, 8(2), 275-286; doi:10.3390/80200275

Article

Synthesis and Biological Evaluation of Some New Coumarin Derivatives

M. A. Al-Haiza ^1,* , M. S. Mostafa ¹  and M. Y. El-Kady ²

¹ Chemistry Department, College of Science, King Khalid University, Abha, P.O.Box 9059, Kingdom of Saudi Arabia ² Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt

* Author to whom correspondence should be addressed.

Received: 21 September 2002; in revised form: 12 January 2003 / Accepted: 15 February 2003 / Published: 28 February 2003

Download PDF Full-Text [57 KB, uploaded 30 September 2008 19:38 CEST]

Abstract: Pyrimidino[5`,4`-6,5]-,pyridino[3`,2`-6,5]- and pyrrolo[3`,2`-5,6]4H-pyrano-[3,2-c][1]benzopyran-6-one derivatives (5-7 and 10) could be obtained via reaction of 2-amino-4-(p-bromophenyl)-3-cyano(carboethoxy)-4H,5H-pyrano[3,2-c][1]benzopyran-5-ones (3a,b) with a variety of reagents. Alkylation of (3b) with either 2-furoyl chloride or chloroacetyl chloride gave the 2-N-substituted derivatives (9a,b). Benzofurano[3,2-b]4H-pyran derivative (12) was also prepared. The antimicrobial activity of the prepared compounds was tested.

Keywords: Pyrano[3; 2-c][1]benzopyran ; pyrimidino[5`; 4`-6; 5]-; pyrrolo[3`; 2`-5; 6]4Hpyrano[ 3; 2-c][1]benzopyran-6-one; antimicrobial activities

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