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• Şunel, V
• Rusu, LBălăiţă
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• Şunel, V
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Molecules 2003, 8(3), 297-309; doi:10.3390/80300297

Article

Immobilization of 1-[N-(M-Nitrobenzoyl)-α-D,L-Asparagyl]-2-Benzylbenzimidazole on Gellan

Marcel Popa ^1,* , Valeriu Şunel ²  and Lăcrămioara Bălăiţă Rusu ¹

¹ Department of Macromolecules, Faculty of Industrial Chemistry, “Gh.Asachi” Technical University of Iaşi, Bd. D. Mangeron, no 71 A, 6600 Iaşi, Romania ² Department of Organic Chemistry “Al.I.Cuza” University of Iaşi, Bd. Carol, no 11, 6600 Iaşi, Romania

* Author to whom correspondence should be addressed.

Received: 27 September 2002; in revised form: 8 March 2003 / Accepted: 10 March 2003 / Published: 31 March 2003

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Abstract: This paper studies the dicyclohexylcarbodiimide activated coupling reaction through ester-type covalent bonds of an oxazolone derived from N-(m-nitrobenzoyl)-L-asparagic acid, ring opened with 2-benzylbenzimidazole, on gellan. Based on a centered, rotatory, composed, second order experimental design, the regression equation describing the dependence of the amount of drug chemically bonded to the support on the reaction parameters is obtained. The efficiency of the coupling reaction over the variation domain established is maximum when the parameters’ highest values are used. The kinetics of the drug’s release from the support are studied under alkaline hydrolysis conditions.

Keywords: Gellan; polymer-drug system; controlled release

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