Molecules 2003, 8(10), 744-755; doi:10.3390/81000744
Article

Synthesis and Reactions of Some New Heterocyclic Carbohydrazides and Related Compounds as Potential Anticancer Agents

1 Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt 2 Central Laboratory for Food and Feed, Agricultural Research Centre, 9 El Gamaa St., Giza, Egypt
* Author to whom correspondence should be addressed.
Received: 1 June 2003; in revised form: 20 August 2003 / Accepted: 25 August 2003 / Published: 31 October 2003
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Abstract: Acylation of 3-hydrazino-5,6-diphenyl-1,2,4-triazine (2) and hydrazine hydrate (7) with 4-aryl-1,3,7-triphenyl-8-oxa-1,2,6-triazaspiro[4.4]nona-2,6-dien-9-ones 5a,b gave the corresponding heterocyclic carbohydrazides 6a,b and 8a,b respectively. Conversion of compounds 8a,b into the versatile carbohydrazide derivatives 9a-g, 10, 13 and the related oxadiazoles 11, 12a,b was undertaken. A primary in vitro test of compound 8a (concentration 10-4 M) showed activity against leukemia cell lines (CCRFCEM, K-256, MOLT-4, PRMI-8226, SR).
Keywords: Synthesis; Pyrazoles; 2-Pyrazolines; Carbohydrazides

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MDPI and ACS Style

Mansour, A.K.; Eid, M.M.; Khalil, N.S.A.M. Synthesis and Reactions of Some New Heterocyclic Carbohydrazides and Related Compounds as Potential Anticancer Agents. Molecules 2003, 8, 744-755.

AMA Style

Mansour AK, Eid MM, Khalil NSAM. Synthesis and Reactions of Some New Heterocyclic Carbohydrazides and Related Compounds as Potential Anticancer Agents. Molecules. 2003; 8(10):744-755.

Chicago/Turabian Style

Mansour, Abdel K.; Eid, Mohga M.; Khalil, Nasser S.A.M. 2003. "Synthesis and Reactions of Some New Heterocyclic Carbohydrazides and Related Compounds as Potential Anticancer Agents." Molecules 8, no. 10: 744-755.

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