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Molecules 2003, 8(10), 744-755; doi:10.3390/81000744
Article

Synthesis and Reactions of Some New Heterocyclic Carbohydrazides and Related Compounds as Potential Anticancer Agents

1,* , 1 and 2
1 Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt 2 Central Laboratory for Food and Feed, Agricultural Research Centre, 9 El Gamaa St., Giza, Egypt
* Author to whom correspondence should be addressed.
Received: 1 June 2003 / Revised: 20 August 2003 / Accepted: 25 August 2003 / Published: 31 October 2003
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Abstract

Acylation of 3-hydrazino-5,6-diphenyl-1,2,4-triazine (2) and hydrazine hydrate (7) with 4-aryl-1,3,7-triphenyl-8-oxa-1,2,6-triazaspiro[4.4]nona-2,6-dien-9-ones 5a,b gave the corresponding heterocyclic carbohydrazides 6a,b and 8a,b respectively. Conversion of compounds 8a,b into the versatile carbohydrazide derivatives 9a-g, 10, 13 and the related oxadiazoles 11, 12a,b was undertaken. A primary in vitro test of compound 8a (concentration 10-4 M) showed activity against leukemia cell lines (CCRFCEM, K-256, MOLT-4, PRMI-8226, SR).
Keywords: Synthesis; Pyrazoles; 2-Pyrazolines; Carbohydrazides Synthesis; Pyrazoles; 2-Pyrazolines; Carbohydrazides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Mansour, A.K.; Eid, M.M.; Khalil, N.S.A.M. Synthesis and Reactions of Some New Heterocyclic Carbohydrazides and Related Compounds as Potential Anticancer Agents. Molecules 2003, 8, 744-755.

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