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• Mansour, AKader
• Eid, MM.
• Khalil, NS. A. M.
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• Eid, MM.
• Khalil, NS. A. M.
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• Eid, MM.
• Khalil, NS. A. M.

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Molecules 2003, 8(10), 744-755; doi:10.3390/81000744

Article

Synthesis and Reactions of Some New Heterocyclic Carbohydrazides and Related Compounds as Potential Anticancer Agents

Abdel Kader Mansour ^1,* , Mohga M. Eid ¹  and Nasser S. A. M. Khalil ²

¹ Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt ² Central Laboratory for Food and Feed, Agricultural Research Centre, 9 El Gamaa St., Giza, Egypt

* Author to whom correspondence should be addressed.

Received: 1 June 2003; in revised form: 20 August 2003 / Accepted: 25 August 2003 / Published: 31 October 2003

Download PDF Full-Text [108 KB, uploaded 30 September 2008 19:38 CEST]

Abstract: Acylation of 3-hydrazino-5,6-diphenyl-1,2,4-triazine (2) and hydrazine hydrate (7) with 4-aryl-1,3,7-triphenyl-8-oxa-1,2,6-triazaspiro[4.4]nona-2,6-dien-9-ones 5a,b gave the corresponding heterocyclic carbohydrazides 6a,b and 8a,b respectively. Conversion of compounds 8a,b into the versatile carbohydrazide derivatives 9a-g, 10, 13 and the related oxadiazoles 11, 12a,b was undertaken. A primary in vitro test of compound 8a (concentration 10^-4 M) showed activity against leukemia cell lines (CCRFCEM, K-256, MOLT-4, PRMI-8226, SR).

Keywords: Synthesis; Pyrazoles; 2-Pyrazolines; Carbohydrazides

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