Next Article in Journal
Synthesis and Biological Evaluation of Quinazoline-4-thiones
Previous Article in Journal
Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System
Molecules 2003, 8(10), 744-755; doi:10.3390/81000744
Article

Synthesis and Reactions of Some New Heterocyclic Carbohydrazides and Related Compounds as Potential Anticancer Agents

1,* , 1 and 2
1 Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt 2 Central Laboratory for Food and Feed, Agricultural Research Centre, 9 El Gamaa St., Giza, Egypt
* Author to whom correspondence should be addressed.
Received: 1 June 2003 / Revised: 20 August 2003 / Accepted: 25 August 2003 / Published: 31 October 2003
View Full-Text   |   Download PDF [108 KB, uploaded 18 June 2014]   |  

Abstract

Acylation of 3-hydrazino-5,6-diphenyl-1,2,4-triazine (2) and hydrazine hydrate (7) with 4-aryl-1,3,7-triphenyl-8-oxa-1,2,6-triazaspiro[4.4]nona-2,6-dien-9-ones 5a,b gave the corresponding heterocyclic carbohydrazides 6a,b and 8a,b respectively. Conversion of compounds 8a,b into the versatile carbohydrazide derivatives 9a-g, 10, 13 and the related oxadiazoles 11, 12a,b was undertaken. A primary in vitro test of compound 8a (concentration 10-4 M) showed activity against leukemia cell lines (CCRFCEM, K-256, MOLT-4, PRMI-8226, SR).
Keywords: Synthesis; Pyrazoles; 2-Pyrazolines; Carbohydrazides Synthesis; Pyrazoles; 2-Pyrazolines; Carbohydrazides
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Mansour, A.K.; Eid, M.M.; Khalil, N.S.A.M. Synthesis and Reactions of Some New Heterocyclic Carbohydrazides and Related Compounds as Potential Anticancer Agents. Molecules 2003, 8, 744-755.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert