Next Article in Journal
Synthesis and Reactions of Some New Heterocyclic Carbohydrazides and Related Compounds as Potential Anticancer Agents
Previous Article in Journal
2-(p-Hydroxybenzyl)indoles - Side Products Formed Upon Cleavage of Indole Derivatives from Carboxylated Wang Polymer - an NMR Study
Article Menu

Export Article

Open AccessArticle
Molecules 2003, 8(10), 735-743; https://doi.org/10.3390/81000735

Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System

1
Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, USA
2
Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt
*
Author to whom correspondence should be addressed.
Received: 29 April 2003 / Revised: 17 August 2003 / Accepted: 18 August 2003 / Published: 31 October 2003
Full-Text   |   PDF [53 KB, uploaded 18 June 2014]   |  

Abstract

A general synthesis of tetronic acid derivatives, namely 4-aroyl-3-alkoxy-2(5H)-furanones, is achieved via the treatment of an anhydrous dimethylformamide (DMF) solution of 4-aroyl-3-hydroxy-2(5H)-furanones with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as base at -10-0°C, followed by the addition of alkyl iodide. Their structural assignments are based on spectroscopic data and confirmed by X-ray crystallography. These furanones were used as starting materials for the preparation of furodiazepines. View Full-Text
Keywords: 4-Aroyl-3-alkoxy-2(5H)-furanones; 7-aryl-4; 5-dihydro-2-oxo-3H; 8H-furo- [3; 4-b][1; 4]diazepines; X-ray structures 4-Aroyl-3-alkoxy-2(5H)-furanones; 7-aryl-4; 5-dihydro-2-oxo-3H; 8H-furo- [3; 4-b][1; 4]diazepines; X-ray structures
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Zimmer, H.; Librera, C.P.; Hausner, S.; Bauer, J.; Amer, A. Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System. Molecules 2003, 8, 735-743.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top