Molecules 2003, 8(10), 735-743; doi:10.3390/81000735
Article

Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System

1, 1, 1, 1 and 2,* email
Received: 29 April 2003; in revised form: 17 August 2003 / Accepted: 18 August 2003 / Published: 31 October 2003
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A general synthesis of tetronic acid derivatives, namely 4-aroyl-3-alkoxy-2(5H)-furanones, is achieved via the treatment of an anhydrous dimethylformamide (DMF) solution of 4-aroyl-3-hydroxy-2(5H)-furanones with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as base at -10-0°C, followed by the addition of alkyl iodide. Their structural assignments are based on spectroscopic data and confirmed by X-ray crystallography. These furanones were used as starting materials for the preparation of furodiazepines.
Keywords: 4-Aroyl-3-alkoxy-2(5H)-furanones; 7-aryl-4; 5-dihydro-2-oxo-3H; 8H-furo- [3; 4-b][1; 4]diazepines; X-ray structures
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MDPI and ACS Style

Zimmer, H.; Librera, C.P.; Hausner, S.; Bauer, J.; Amer, A. Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System. Molecules 2003, 8, 735-743.

AMA Style

Zimmer H, Librera CP, Hausner S, Bauer J, Amer A. Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System. Molecules. 2003; 8(10):735-743.

Chicago/Turabian Style

Zimmer, Hans; Librera, Christian P.; Hausner, Sven; Bauer, Jeanette; Amer, Adel. 2003. "Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System." Molecules 8, no. 10: 735-743.

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