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Molecules 2002, 7(6), 487-493; doi:10.3390/70600487
Article

An Efficient Preparation of 1,2-Diamino-1-phenylheptane

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Received: 12 December 2001 / Revised: 24 June 2002 / Accepted: 25 June 2002 / Published: 30 June 2002
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Abstract

A convenient four-step method for the preparation of the lipophilic vicinal diamine 1,2-diamino-1-phenylheptane is described. Condensation involving octan-2-one, benzaldehyde and ammonia is reported. Regioselective Schmidt rearrangement of 2,6-diphenyl-3-pentyl-piperidin-4-one (1) to 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one (3) is presented. Hydrolysis of 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one to 1,2-diamino-1-phenylheptane (4) is also reported for the first time.
Keywords: Piperidinone; Schmidt rearrangement; Hexahydrodiazapinone; Vicinal diamine Piperidinone; Schmidt rearrangement; Hexahydrodiazapinone; Vicinal diamine
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Thennarasu, S.; Perumal, P.T. An Efficient Preparation of 1,2-Diamino-1-phenylheptane. Molecules 2002, 7, 487-493.

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