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Molecules 2001, 6(9), 784-795; doi:10.3390/60900784
Article

Biologically Active 1-Arylpiperazines. Synthesis of New N-(4-Aryl-1-piperazinyl)alkyl Derivatives of Quinazolidin-4(3H)-one, 2,3-Dihydrophthalazine-1,4-dione and 1,2-Dihydropyridazine-3,6-dione as Potential Serotonin Receptor Ligands

1,* , 1, 2, 2 and 2
1 Institute of Organic Chemistry and Technology, Cracow University of Technology, 24 Warszawska str., 31-155 Cracow, Poland 2 Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna str., 31-343 Cracow, Poland
* Author to whom correspondence should be addressed.
Received: 26 February 2001 / Revised: 28 August 2001 / Accepted: 28 August 2001 / Published: 31 August 2001
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Abstract

The synthesis of a series of new n-propyl and n-butyl chain containing 1-arylpiperazine derivatives of quinazolidin-4(3H)-one (7) 2-phenyl-2,3-dihydrophthalazine-1,4-dione (8) and 1-phenyl-1,2-dihydropyridazine-3,6-dione (9) as potential serotonin receptor ligands is described.
Keywords: Arylpiperazines; lactams; serotonin receptor ligands Arylpiperazines; lactams; serotonin receptor ligands
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Kowalski, P.; Kowalska, T.; Mokrosz, M.J.; Bojarski, A.J.; Charakchieva-Minol, S. Biologically Active 1-Arylpiperazines. Synthesis of New N-(4-Aryl-1-piperazinyl)alkyl Derivatives of Quinazolidin-4(3H)-one, 2,3-Dihydrophthalazine-1,4-dione and 1,2-Dihydropyridazine-3,6-dione as Potential Serotonin Receptor Ligands. Molecules 2001, 6, 784-795.

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