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Molecules 2001, 6(8), 710-715; doi:10.3390/60800710
Article

Synthesis of 1-Benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-Rstyryl)-2,3-dihydropyrazolo[3,4-b][1,4]diazepines

1,* , 1, 1, 1, 2,* , 2 and 3
1 Grupo de Investigación de Compuestos Heterocíclicos, Departamento de Química, Universidad del Valle, A.A. 25360, Cali, Colombia 2 Instituto de Química, UNAM, Circuito Exterior, C. Universitaria, Coyoacán, 04510, México, D. F. México 3 Laboratorio de Química Medicinal, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Cuautitlán, Estado de México, México
* Authors to whom correspondence should be addressed.
Received: 14 December 2000 / Revised: 20 July 2001 / Accepted: 26 July 2001 / Published: 31 July 2001
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Abstract

The reaction of 4-amino-5-benzylamino-3-(4-chlorophenyl)-1H-pyrazole (1) with substituted diarylidenketones (2) constitutes a convenient synthetic route to the hitherto unknown 1-benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-R-styryl)-2,3-dihydropyrazolo-[3,4-b][1,4]diazepines (3). Structures of all products were consistent with their IR, 1H-NMR, 13C-NMR and MS spectral data. X-ray crystallography data confirm the assigned structures.
Keywords: Diazepine derivatives; diarylidenketones Diazepine derivatives; diarylidenketones
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Insuasty, B.; Rodríguez, R.; Quiroga, J.; Abonía, R.; Martínez, R.; Toscano, A.; Angeles, E. Synthesis of 1-Benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-Rstyryl)-2,3-dihydropyrazolo[3,4-b][1,4]diazepines. Molecules 2001, 6, 710-715.

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