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One-Pot Quinazolin-4-ylidenethiourea Synthesis via N-(2-Cyanophenyl)benzimidoyl isothiocyanate
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Molecules 2001, 6(7), 588-602; doi:10.3390/60700588

One-Pot Quinazolin-4-yl-thiourea Synthesis via N-(2-Cyanophenyl) benzimidoyl isothiocyanate

1
Department of Organic Chemistry, Faculty of Science, Masaryk University, Brno, Czech Republic
2
Laboratory of Biomolecular Structure and Dynamics, Faculty of Science, Masaryk University, Brno, Czech Republic
3
Department of Inorganic Chemistry, Masaryk University, 611 37 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Received: 10 November 2000 / Revised: 22 May 2001 / Accepted: 23 May 2001 / Published: 30 June 2001
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Abstract

1-substituted-3-(2-phenylquinazolin-4-yl) thioureas (7) were produced by an intramolecular cycloaddition reaction of 1-substitued-3-[(2-cyanophenylimino) phenylmethyl] thioureas (3). These compounds in turn were prepared by the reaction of N-(2-cyanophenyl)benzimidoyl isothiocyanate (2) with primary amines. The structures of products 7 were confirmed by FTIR, 1H-NMR, 13C-NMR, mass spectroscopy and X-ray crystallography.
Keywords: 1-(2-phenylquinazolin-4-yl)-3-substituted thioureas; 1-[(2-cyanophenylimino) phenylmethyl]-3-substituted thioureas; N-(2-cyanophenyl)- benzimidoyl isothiocyanate; one-pot synthesis; amidinoyl isothiocyanates 1-(2-phenylquinazolin-4-yl)-3-substituted thioureas; 1-[(2-cyanophenylimino) phenylmethyl]-3-substituted thioureas; N-(2-cyanophenyl)- benzimidoyl isothiocyanate; one-pot synthesis; amidinoyl isothiocyanates
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Fathalla, W.; Čajan, M.; Marek, J.; Pazdera, P. One-Pot Quinazolin-4-yl-thiourea Synthesis via N-(2-Cyanophenyl) benzimidoyl isothiocyanate. Molecules 2001, 6, 588-602.

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