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Molecules 2001, 6(7), 603-613; doi:10.3390/60700603
Article

Some Anilides of 2-Alkylthio- and 2-Chloro-6-Alkylthio-4-Pyridinecarboxylic Acids: Synthesis and Photosynthesis-Inhibiting Activity

1,* , 1, 1, 1, 2 and 3
1 Department of Medicinal Chemistry and Drug Control, Charles University, Faculty of Pharmacy, 500 05 Hradec Králové, Czech Republic 2 Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic 3 Department of Inorganic and Organic Chemistry, Charles University, Faculty of Pharmacy, 500 05 Hradec Králové, Czech Republic
* Author to whom correspondence should be addressed.
Received: 16 February 2001 / Revised: 28 May 2001 / Accepted: 1 May 2001 / Published: 30 June 2001
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Abstract

Many compounds containing a -CONH- group display photosynthesis inhibiting activity. Based on this structural feature, a group of anilides of 2-alkylthio-(1b-4f) or 2-chloro-6-alkylthio-4-pyridinecarboxylic acids (5a-6c) was synthesised. The prepared compounds were tested for their inhibition of the oxygen evolution rate (OER) in spinach chloroplasts. A quasi-parabolic dependence between photosynthesis-inhibiting activity and the lipophilicity of the compounds was determined for 1b-4f as well as for 5a-6c. The inhibitory activity of compounds 1b-4f was higher than that of 5a-6c for comparable lipophilicity values.
Keywords: 2-Alkylthio-4-pyridinecarboxylic acids; Anilides; Photosynthesis inhibition 2-Alkylthio-4-pyridinecarboxylic acids; Anilides; Photosynthesis inhibition
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Miletín, M.; Doležal, M.; Opletalová, V.; Hartl, J.; Král’ová, K.; Macháček, M. Some Anilides of 2-Alkylthio- and 2-Chloro-6-Alkylthio-4-Pyridinecarboxylic Acids: Synthesis and Photosynthesis-Inhibiting Activity. Molecules 2001, 6, 603-613.

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