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Molecules 2001, 6(7), 603-613; doi:10.3390/60700603
Article

Some Anilides of 2-Alkylthio- and 2-Chloro-6-Alkylthio-4-Pyridinecarboxylic Acids: Synthesis and Photosynthesis-Inhibiting Activity

1,* , 1, 1, 1, 2 and 3
1 Department of Medicinal Chemistry and Drug Control, Charles University, Faculty of Pharmacy, 500 05 Hradec Králové, Czech Republic 2 Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic 3 Department of Inorganic and Organic Chemistry, Charles University, Faculty of Pharmacy, 500 05 Hradec Králové, Czech Republic
* Author to whom correspondence should be addressed.
Received: 16 February 2001 / Revised: 28 May 2001 / Accepted: 1 May 2001 / Published: 30 June 2001
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Abstract

Many compounds containing a -CONH- group display photosynthesis inhibiting activity. Based on this structural feature, a group of anilides of 2-alkylthio-(1b-4f) or 2-chloro-6-alkylthio-4-pyridinecarboxylic acids (5a-6c) was synthesised. The prepared compounds were tested for their inhibition of the oxygen evolution rate (OER) in spinach chloroplasts. A quasi-parabolic dependence between photosynthesis-inhibiting activity and the lipophilicity of the compounds was determined for 1b-4f as well as for 5a-6c. The inhibitory activity of compounds 1b-4f was higher than that of 5a-6c for comparable lipophilicity values.
Keywords: 2-Alkylthio-4-pyridinecarboxylic acids; Anilides; Photosynthesis inhibition 2-Alkylthio-4-pyridinecarboxylic acids; Anilides; Photosynthesis inhibition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Miletín, M.; Doležal, M.; Opletalová, V.; Hartl, J.; Král’ová, K.; Macháček, M. Some Anilides of 2-Alkylthio- and 2-Chloro-6-Alkylthio-4-Pyridinecarboxylic Acids: Synthesis and Photosynthesis-Inhibiting Activity. Molecules 2001, 6, 603-613.

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