Next Article in Journal
One-Pot Quinazolin-4-yl-thiourea Synthesis via N-(2-Cyanophenyl) benzimidoyl isothiocyanate
Previous Article in Journal
Regioselectivity of Electrophilic Attack on 4-Methyl-1-thioxo-1,2,4,5-tetrahydro[1,2,4]triazolo[4,3-a]quinazolin-5-one. Part 1: Reactions at the Sulfur Atom
Molecules 2001, 6(7), 574-587; doi:10.3390/60700574
Article

One-Pot Quinazolin-4-ylidenethiourea Synthesis via N-(2-Cyanophenyl)benzimidoyl isothiocyanate

1, 1,2, 3 and 1,*
1 Department of Organic Chemistry, Faculty of Science, Masaryk University, Brno, Czech Republic 2 National Center for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic 3 Department of Inorganic Chemistry, Masaryk University, 611 37 Brno, Czech Republic
* Author to whom correspondence should be addressed.
Received: 10 November 2000 / Revised: 22 May 2001 / Accepted: 23 May 2001 / Published: 30 June 2001
View Full-Text   |   Download PDF [226 KB, uploaded 18 June 2014]   |   Browse Figures

Abstract

1,1-Disubstituted-3-(2-phenyl-3H-quinazolin-4-ylidene)thioureas (8) were synthesized in a one pot reaction of N-(2-cyanophenyl)benzimidoyl isothicyanate (3) with secondary amines. The products underwent transamination reactions. Compounds 8a-8g were identified by FTIR, 1H-NMR, 13C-NMR, mass spectroscopy and X-ray crystallography.
Keywords: N-(2-cyanophenyl)benzimidoyl isothicyanate; 1; 1-disubstituted-3-(2-phenyl- 3H-quinazolin-4-ylidene)thioureas; intramolecular cycloaddition; 1; 1-disubstituted-3-[(2- cyanophenylimino)phenylmethyl]thioureas; quinazolines N-(2-cyanophenyl)benzimidoyl isothicyanate; 1; 1-disubstituted-3-(2-phenyl- 3H-quinazolin-4-ylidene)thioureas; intramolecular cycloaddition; 1; 1-disubstituted-3-[(2- cyanophenylimino)phenylmethyl]thioureas; quinazolines
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Fathalla, W.M.; Čajan, M.; Marek, J.; Pazdera, P. One-Pot Quinazolin-4-ylidenethiourea Synthesis via N-(2-Cyanophenyl)benzimidoyl isothiocyanate. Molecules 2001, 6, 574-587.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert