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Regioselectivity of Electrophilic Attack on 4-Methyl-1-thioxo-1,2,4,5-tetrahydro[1,2,4]triazolo[4,3-a]quinazolin-5-one. Part 1: Reactions at the Sulfur Atom
Molecules 2001, 6(7), 574-587; doi:10.3390/60700574
Article

One-Pot Quinazolin-4-ylidenethiourea Synthesis via N-(2-Cyanophenyl)benzimidoyl isothiocyanate

1, 1,2, 3 and 1,*
Received: 10 November 2000 / Revised: 22 May 2001 / Accepted: 23 May 2001 / Published: 30 June 2001
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Abstract

1,1-Disubstituted-3-(2-phenyl-3H-quinazolin-4-ylidene)thioureas (8) were synthesized in a one pot reaction of N-(2-cyanophenyl)benzimidoyl isothicyanate (3) with secondary amines. The products underwent transamination reactions. Compounds 8a-8g were identified by FTIR, 1H-NMR, 13C-NMR, mass spectroscopy and X-ray crystallography.
Keywords: N-(2-cyanophenyl)benzimidoyl isothicyanate; 1; 1-disubstituted-3-(2-phenyl- 3H-quinazolin-4-ylidene)thioureas; intramolecular cycloaddition; 1; 1-disubstituted-3-[(2- cyanophenylimino)phenylmethyl]thioureas; quinazolines N-(2-cyanophenyl)benzimidoyl isothicyanate; 1; 1-disubstituted-3-(2-phenyl- 3H-quinazolin-4-ylidene)thioureas; intramolecular cycloaddition; 1; 1-disubstituted-3-[(2- cyanophenylimino)phenylmethyl]thioureas; quinazolines
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Fathalla, W.M.; Čajan, M.; Marek, J.; Pazdera, P. One-Pot Quinazolin-4-ylidenethiourea Synthesis via N-(2-Cyanophenyl)benzimidoyl isothiocyanate. Molecules 2001, 6, 574-587.

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