Molecules 2001, 6(7), 574-587; doi:10.3390/60700574
Article

One-Pot Quinazolin-4-ylidenethiourea Synthesis via N-(2-Cyanophenyl)benzimidoyl isothiocyanate

Walid M. Fathalla 1 , Michal Čajan 1,2 , Jaromír Marek 3  and Pavel Pazdera 1,* email
1 Department of Organic Chemistry, Faculty of Science, Masaryk University, Brno, Czech Republic 2 National Center for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic 3 Department of Inorganic Chemistry, Masaryk University, 611 37 Brno, Czech Republic
* Author to whom correspondence should be addressed.
Received: 10 November 2000; in revised form: 22 May 2001 / Accepted: 23 May 2001 / Published: 30 June 2001
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Abstract: 1,1-Disubstituted-3-(2-phenyl-3H-quinazolin-4-ylidene)thioureas (8) were synthesized in a one pot reaction of N-(2-cyanophenyl)benzimidoyl isothicyanate (3) with secondary amines. The products underwent transamination reactions. Compounds 8a-8g were identified by FTIR, 1H-NMR, 13C-NMR, mass spectroscopy and X-ray crystallography.
Keywords: N-(2-cyanophenyl)benzimidoyl isothicyanate; 1; 1-disubstituted-3-(2-phenyl- 3H-quinazolin-4-ylidene)thioureas; intramolecular cycloaddition; 1; 1-disubstituted-3-[(2- cyanophenylimino)phenylmethyl]thioureas; quinazolines

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MDPI and ACS Style

Fathalla, W.M.; Čajan, M.; Marek, J.; Pazdera, P. One-Pot Quinazolin-4-ylidenethiourea Synthesis via N-(2-Cyanophenyl)benzimidoyl isothiocyanate. Molecules 2001, 6, 574-587.

AMA Style

Fathalla WM, Čajan M, Marek J, Pazdera P. One-Pot Quinazolin-4-ylidenethiourea Synthesis via N-(2-Cyanophenyl)benzimidoyl isothiocyanate. Molecules. 2001; 6(7):574-587.

Chicago/Turabian Style

Fathalla, Walid M.; Čajan, Michal; Marek, Jaromír; Pazdera, Pavel. 2001. "One-Pot Quinazolin-4-ylidenethiourea Synthesis via N-(2-Cyanophenyl)benzimidoyl isothiocyanate." Molecules 6, no. 7: 574-587.

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