Zn Mediated Regioselective Barbier Reaction of Propargylic Bromides in THF/aq. NH4Cl Solution

doi:10.3390/61200964

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Molecules 2001, 6(12), 964-968; doi:10.3390/61200964

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Zn Mediated Regioselective Barbier Reaction of Propargylic Bromides in THF/aq. NH₄Cl Solution

Artur Jõgi and Uno Mäeorg*

Institute of Organic Chemistry, University of Tartu, Jakobi 2, Tartu, 51014, Estonia

* Author to whom correspondence should be addressed.

Received: 9 January 2001; in revised form: 31 October 2001 / Accepted: 31 October 2001 / Published: 30 November 2001

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Abstract: The reaction of substituted and unsubstituted propargylic bromides with butanal in presence of zinc power in THF/saturated aqueous NH₄Cl solution gave corresponding allenic and propargylic alcohols with high selectivity.

Keywords: Allenic alcohol; regiospecific Barbier reaction; propargylic bromides; zinc

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MDPI and ACS Style

Jõgi, A.; Mäeorg, U. Zn Mediated Regioselective Barbier Reaction of Propargylic Bromides in THF/aq. NH₄Cl Solution. Molecules 2001, 6, 964-968.

AMA Style

Jõgi A, Mäeorg U. Zn Mediated Regioselective Barbier Reaction of Propargylic Bromides in THF/aq. NH₄Cl Solution. Molecules. 2001; 6(12):964-968.

Chicago/Turabian Style

Jõgi, Artur; Mäeorg, Uno. 2001. "Zn Mediated Regioselective Barbier Reaction of Propargylic Bromides in THF/aq. NH₄Cl Solution." Molecules 6, no. 12: 964-968.

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