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Molecules 2001, 6(12), 964-968; doi:10.3390/61200964
Article

Zn Mediated Regioselective Barbier Reaction of Propargylic Bromides in THF/aq. NH4Cl Solution

 and *
Institute of Organic Chemistry, University of Tartu, Jakobi 2, Tartu, 51014, Estonia
* Author to whom correspondence should be addressed.
Received: 9 January 2001 / Revised: 31 October 2001 / Accepted: 31 October 2001 / Published: 30 November 2001
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Abstract

The reaction of substituted and unsubstituted propargylic bromides with butanal in presence of zinc power in THF/saturated aqueous NH4Cl solution gave corresponding allenic and propargylic alcohols with high selectivity.
Keywords: Allenic alcohol; regiospecific Barbier reaction; propargylic bromides; zinc Allenic alcohol; regiospecific Barbier reaction; propargylic bromides; zinc
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Jõgi, A.; Mäeorg, U. Zn Mediated Regioselective Barbier Reaction of Propargylic Bromides in THF/aq. NH4Cl Solution. Molecules 2001, 6, 964-968.

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