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Molecules 2001, 6(12), 959-963; doi:10.3390/61200959

An Improved Synthesis of 5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog)

Institute of Organic Chemistry, VUT, A-1060 Vienna, Getreidemarkt 9, Austria
Iconix Pharmaceuticals, Inc., 830 Maude Avenue, Mountain View, CA 94043, USA
Author to whom correspondence should be addressed.
Received: 22 October 2001 / Revised: 30 October 2001 / Accepted: 30 October 2001 / Published: 30 November 2001
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An improved procedure for the synthesis an analog of the p38 inhibitor compound VX- 745 is reported. View Full-Text
Keywords: nucleophilic substitution; DMF-acetal heterocyclization nucleophilic substitution; DMF-acetal heterocyclization

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Treu, M.; Jordis, U.; Lee, V.J. An Improved Synthesis of 5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog). Molecules 2001, 6, 959-963.

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