An Improved Synthesis of 5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog)

doi:10.3390/61200959

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Molecules 2001, 6(12), 959-963; doi:10.3390/61200959

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An Improved Synthesis of 5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog)

Matthias Treu¹, Ulrich Jordis^1,* and Ving J. Lee²

¹ Institute of Organic Chemistry, VUT, A-1060 Vienna, Getreidemarkt 9, Austria ² Iconix Pharmaceuticals, Inc., 830 Maude Avenue, Mountain View, CA 94043, USA

* Author to whom correspondence should be addressed.

Received: 22 October 2001; in revised form: 30 October 2001 / Accepted: 30 October 2001 / Published: 30 November 2001

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Abstract: An improved procedure for the synthesis an analog of the p38 inhibitor compound VX- 745 is reported.

Keywords: nucleophilic substitution; DMF-acetal heterocyclization

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MDPI and ACS Style

Treu, M.; Jordis, U.; Lee, V.J. An Improved Synthesis of 5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog). Molecules 2001, 6, 959-963.

AMA Style

Treu M., Jordis U., Lee V.J. An Improved Synthesis of 5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog). Molecules. 2001; 6(12):959-963.

Chicago/Turabian Style

Treu, Matthias; Jordis, Ulrich; Lee, Ving J. 2001. "An Improved Synthesis of 5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog)." Molecules 6, no. 12: 959-963.

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