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Molecules 2001, 6(12), 959-963; doi:10.3390/61200959
Article

An Improved Synthesis of 5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog)

1, 1,*  and 2
1 Institute of Organic Chemistry, VUT, A-1060 Vienna, Getreidemarkt 9, Austria 2 Iconix Pharmaceuticals, Inc., 830 Maude Avenue, Mountain View, CA 94043, USA
* Author to whom correspondence should be addressed.
Received: 22 October 2001 / Revised: 30 October 2001 / Accepted: 30 October 2001 / Published: 30 November 2001
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Abstract

An improved procedure for the synthesis an analog of the p38 inhibitor compound VX- 745 is reported.
Keywords: nucleophilic substitution; DMF-acetal heterocyclization nucleophilic substitution; DMF-acetal heterocyclization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Treu, M.; Jordis, U.; Lee, V.J. An Improved Synthesis of 5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog). Molecules 2001, 6, 959-963.

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