Next Article in Journal
Zn Mediated Regioselective Barbier Reaction of Propargylic Bromides in THF/aq. NH4Cl Solution
Previous Article in Journal
Some Heteroaromatic Organomercurials, Their Syntheses and Reactions: A Review of Our Research (1980-2000)
Article Menu

Export Article

Open AccessArticle
Molecules 2001, 6(12), 959-963; https://doi.org/10.3390/61200959

An Improved Synthesis of 5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog)

1
Institute of Organic Chemistry, VUT, A-1060 Vienna, Getreidemarkt 9, Austria
2
Iconix Pharmaceuticals, Inc., 830 Maude Avenue, Mountain View, CA 94043, USA
*
Author to whom correspondence should be addressed.
Received: 22 October 2001 / Revised: 30 October 2001 / Accepted: 30 October 2001 / Published: 30 November 2001
View Full-Text   |   Download PDF [27 KB, uploaded 18 June 2014]   |  

Abstract

An improved procedure for the synthesis an analog of the p38 inhibitor compound VX- 745 is reported. View Full-Text
Keywords: nucleophilic substitution; DMF-acetal heterocyclization nucleophilic substitution; DMF-acetal heterocyclization
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Treu, M.; Jordis, U.; Lee, V.J. An Improved Synthesis of 5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog). Molecules 2001, 6, 959-963.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top