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Molecules 2001, 6(12), 969-978; doi:10.3390/61200969
Article

Regioselectivity in the Thermal Rearrangement of Unsymmetrical 4-Methyl-4H-1,2,4-triazoles to 1-Methyl-1H-1,2,4-triazoles

 and *
Department of Chemistry, Norwegian University of Science and Technology, N-7491 Trondheim, Norway
* Author to whom correspondence should be addressed.
Received: 14 March 2001 / Revised: 26 October 2001 / Accepted: 26 October 2001 / Published: 30 November 2001
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Abstract

The rearrangement of 4-methyl-3,5-diaryl-4H-1,2,4-triazoles to the corresponding 1-methyl-3,5-diaryl-1H-1,2,4-triazoles showed regioselectivity comparable to that observed for the alkylation of 3,5-diaryl-1H-1,2,4-triazoles. This lends support to a proposed mechanism for the rearrangement that involves consecutive nucleophilic displacements steps.
Keywords: Thermolysis; 1; 2; 4-triazole; Rearrangement; Regioselective Thermolysis; 1; 2; 4-triazole; Rearrangement; Regioselective
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gautun, O.R.; Carlsen, P.H. Regioselectivity in the Thermal Rearrangement of Unsymmetrical 4-Methyl-4H-1,2,4-triazoles to 1-Methyl-1H-1,2,4-triazoles. Molecules 2001, 6, 969-978.

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