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Molecules 2001, 6(12), 969-978; doi:10.3390/61200969
Article

Regioselectivity in the Thermal Rearrangement of Unsymmetrical 4-Methyl-4H-1,2,4-triazoles to 1-Methyl-1H-1,2,4-triazoles

 and *
Department of Chemistry, Norwegian University of Science and Technology, N-7491 Trondheim, Norway
* Author to whom correspondence should be addressed.
Received: 14 March 2001 / Revised: 26 October 2001 / Accepted: 26 October 2001 / Published: 30 November 2001
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Abstract

The rearrangement of 4-methyl-3,5-diaryl-4H-1,2,4-triazoles to the corresponding 1-methyl-3,5-diaryl-1H-1,2,4-triazoles showed regioselectivity comparable to that observed for the alkylation of 3,5-diaryl-1H-1,2,4-triazoles. This lends support to a proposed mechanism for the rearrangement that involves consecutive nucleophilic displacements steps.
Keywords: Thermolysis; 1; 2; 4-triazole; Rearrangement; Regioselective Thermolysis; 1; 2; 4-triazole; Rearrangement; Regioselective
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Gautun, O.R.; Carlsen, P.H. Regioselectivity in the Thermal Rearrangement of Unsymmetrical 4-Methyl-4H-1,2,4-triazoles to 1-Methyl-1H-1,2,4-triazoles. Molecules 2001, 6, 969-978.

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