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Molecules 2001, 6(10), 815-824; doi:10.3390/61000815

Synthesis, Antibacterial and Antifungal Activity of 4-Substituted-5-Aryl-1,2,4-Triazoles

1, 1,* , 2, 3 and 1
1 Faculty of Technology and Metallurgy, The “Sv. Kiril & Metodij” University, R. Boskovic 16, 1000 Skopje, Macedonia 2 Faculty of Agriculture, Department of Microbiology, The “Sv. Kiril & Metodij” University, Bul. Aleksandar Makedonski, bb, 1000 Skopje, Macedonia 3 Institute of Chemistry, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 3, 21000 Novi Sad, Yugoslavia
* Author to whom correspondence should be addressed.
Received: 8 February 2001 / Revised: 24 September 2001 / Accepted: 26 September 2001 / Published: 30 September 2001
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A few 4-allyl/amino-5-aryl-1,2,4-triazoles were synthesized and tested for antibacterial and antifungal effects against Escherichia coli, Bacillus subtilis, Salmonella enteritidis, Staphylococcus aureus, Aspergillus niger and Candida albicans. 4-Allyl-5-aryl-1,2,4-triazoles were obtained by the oxidative cyclization of the appropriate 1-substituted-4-allylthiosemicarbazides and 4-amino-5-aryl-1,2,4-triazoles were obtained by cyclization of the potassium salts of appropriately substituted dithiocarbazinic acids with hydrazine hydrate. The new synthesized compounds were characterized using IR, 1H- NMR, 13C-NMR and UV spectral data together with elemental analysis.
Keywords: Substituted benzoyl/phenylcetyl-4-allylthiosemicarbazides; 1; 2; 4-triazoles; cyclization; inhibition zone Substituted benzoyl/phenylcetyl-4-allylthiosemicarbazides; 1; 2; 4-triazoles; cyclization; inhibition zone
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Colanceska-Ragenovic, K.; Dimova, V.; Kakurinov, V.; Molnar, D.G.; Buzarovska, A. Synthesis, Antibacterial and Antifungal Activity of 4-Substituted-5-Aryl-1,2,4-Triazoles. Molecules 2001, 6, 815-824.

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