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Synthesis, Antibacterial and Antifungal Activity of 4-Substituted-5-Aryl-1,2,4-Triazoles
Faculty of Technology and Metallurgy, The “Sv. Kiril & Metodij” University, R. Boskovic 16, 1000 Skopje, Macedonia
Faculty of Agriculture, Department of Microbiology, The “Sv. Kiril & Metodij” University, Bul. Aleksandar Makedonski, bb, 1000 Skopje, Macedonia
Institute of Chemistry, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 3, 21000 Novi Sad, Yugoslavia
* Author to whom correspondence should be addressed.
Received: 8 February 2001; in revised form: 24 September 2001 / Accepted: 26 September 2001 / Published: 30 September 2001
Abstract: A few 4-allyl/amino-5-aryl-1,2,4-triazoles were synthesized and tested for antibacterial and antifungal effects against Escherichia coli, Bacillus subtilis, Salmonella enteritidis, Staphylococcus aureus, Aspergillus niger and Candida albicans. 4-Allyl-5-aryl-1,2,4-triazoles were obtained by the oxidative cyclization of the appropriate 1-substituted-4-allylthiosemicarbazides and 4-amino-5-aryl-1,2,4-triazoles were obtained by cyclization of the potassium salts of appropriately substituted dithiocarbazinic acids with hydrazine hydrate. The new synthesized compounds were characterized using IR, 1H- NMR, 13C-NMR and UV spectral data together with elemental analysis.
Keywords: Substituted benzoyl/phenylcetyl-4-allylthiosemicarbazides; 1; 2; 4-triazoles; cyclization; inhibition zone
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Colanceska-Ragenovic, K.; Dimova, V.; Kakurinov, V.; Molnar, D.G.; Buzarovska, A. Synthesis, Antibacterial and Antifungal Activity of 4-Substituted-5-Aryl-1,2,4-Triazoles. Molecules 2001, 6, 815-824.
Colanceska-Ragenovic K, Dimova V, Kakurinov V, Molnar DG, Buzarovska A. Synthesis, Antibacterial and Antifungal Activity of 4-Substituted-5-Aryl-1,2,4-Triazoles. Molecules. 2001; 6(10):815-824.
Colanceska-Ragenovic, Katica; Dimova, Vesna; Kakurinov, Vlado; Molnar, Dora G.; Buzarovska, Aleksandra. 2001. "Synthesis, Antibacterial and Antifungal Activity of 4-Substituted-5-Aryl-1,2,4-Triazoles." Molecules 6, no. 10: 815-824.