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Molecules 2000, 5(6), 856-863; doi:10.3390/50600856

Synthetic Analogue of Stilbene Containing an Imidazole Nucleus

Laboratory for Drug Design and Synthesis, Department of Chemistry & Biochemistry, University of Maryland, Baltimore County (UMBC), 1000 Hilltop Circle, Baltimore, Maryland 21250, USA
Author to whom correspondence should be addressed.
Received: 24 May 2000 / Accepted: 13 June 2000 / Published: 18 June 2000
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Synthesis of trans-1,2-bis(4-nitro-1-p-methoxybenzylimidazol-5-yl)ethene (1) as an imidazole analogue of stilbene has been reported. In order to confirm the trans geometry of the product using an UV spectral comparison, a mixture of both trans (1) and cis isomer (3) was also prepared. The synthesis involved one-step dimerization of the precursor, 4-nitro-1-p-methoxybenzyl-5-methyl-1H-imidazole (2), using N-chlorosuccinimide catalyzed by potassium t-butoxide.
Keywords: Dimerization; heterocycles; biaryls; imidazole; stilbene Dimerization; heterocycles; biaryls; imidazole; stilbene
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Siddiqui, S.; Hosmane, R.S. Synthetic Analogue of Stilbene Containing an Imidazole Nucleus. Molecules 2000, 5, 856-863.

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