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Synthetic Analogue of Stilbene Containing an Imidazole Nucleus
Laboratory for Drug Design and Synthesis, Department of Chemistry & Biochemistry, University of Maryland, Baltimore County (UMBC), 1000 Hilltop Circle, Baltimore, Maryland 21250, USA
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Received: 24 May 2000; Accepted: 13 June 2000 / Published: 18 June 2000
Abstract: Synthesis of trans-1,2-bis(4-nitro-1-p-methoxybenzylimidazol-5-yl)ethene (1) as an imidazole analogue of stilbene has been reported. In order to confirm the trans geometry of the product using an UV spectral comparison, a mixture of both trans (1) and cis isomer (3) was also prepared. The synthesis involved one-step dimerization of the precursor, 4-nitro-1-p-methoxybenzyl-5-methyl-1H-imidazole (2), using N-chlorosuccinimide catalyzed by potassium t-butoxide.
Keywords: Dimerization; heterocycles; biaryls; imidazole; stilbene
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Siddiqui, S.; Hosmane, R.S. Synthetic Analogue of Stilbene Containing an Imidazole Nucleus. Molecules 2000, 5, 856-863.
Siddiqui S, Hosmane RS. Synthetic Analogue of Stilbene Containing an Imidazole Nucleus. Molecules. 2000; 5(6):856-863.
Siddiqui, Saika; Hosmane, Ramachandra S. 2000. "Synthetic Analogue of Stilbene Containing an Imidazole Nucleus." Molecules 5, no. 6: 856-863.