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• Kralova, K
• Loos, D
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Molecules 1999, 4(3), 73-80; doi:10.3390/40300073

Article

3-(2-Alkylsulfanyl-6-benzothiazolylaminomethyl)-2-benzoxazolethiones - Synthesis and Photosynthesis-Inhibiting Activity in Spinach Chloropasts

Eva Sidoova, Katarina Kralova and Dusan Loos*

Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina CH-2, SK- 842 15 Bratislava, Slovakia

* Author to whom correspondence should be addressed.

Received: 12 May 1998 / Accepted: 5 March 1999 / Published: 29 March 1999

Download PDF Full-Text [31 KB, uploaded 10 October 2008 08:50 CEST]

Abstract: The synthesis and photosynthesis-inhibiting activity of 14 new 3-(2-alkylsulfanyl-6-benzothiazolylaminomethyl)-2-benzoxazolethiones are reported. The new compounds were prepared by the reaction of 2-alkylsulfanyl-6-aminobenzothiazoles with 3-hydroxymethyl-2-benzoxazolethione. The structures of the compounds were verified by ¹H NMR spectra. The compounds inhibit photosynthetic electron transport in spinach chloroplasts. The photosynthetic activity was found to depend on the calculated lipophilicity of the new compounds. Some structure characteristics and quantum chemical parameters were calculated by AM1 method.

Keywords: Photosynthetic electron transfer inhibition; AM1 quantum chemical method; QSAR; calculated lipophilicity; 3-(2-alkylsulfanyl-6-benzothiazolylaminomethyl)-2- benzoxazolethiones

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