Molecules 1998, 3(3), 80-87; doi:10.3390/30300080
Article

Synthesis of (2R,5R)-2-Amino-5-Hydroxyhexanoic Acid by Intramolecular Cycloaddition

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Received: 15 January 1998; Accepted: 23 February 1998 / Published: 24 February 1998
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The title compound was synthesized from sorbic acid by an eight step sequence. The key step was the stereospecific intramolecular Diels-Alder reaction of the acylnitroso derivative of N-sorbyl-L-proline (5). L-Proline served as a temporary tether which directed both the stereochemistry and the regiochemistry of the cycloaddition.
Keywords: Intramolecular cycloaddition; enantiospecifity; proline; acylnitroso
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MDPI and ACS Style

Sheradsky, T.; Silcoff, E.R. Synthesis of (2R,5R)-2-Amino-5-Hydroxyhexanoic Acid by Intramolecular Cycloaddition. Molecules 1998, 3, 80-87.

AMA Style

Sheradsky T, Silcoff ER. Synthesis of (2R,5R)-2-Amino-5-Hydroxyhexanoic Acid by Intramolecular Cycloaddition. Molecules. 1998; 3(3):80-87.

Chicago/Turabian Style

Sheradsky, Tuvia; Silcoff, Elliad R. 1998. "Synthesis of (2R,5R)-2-Amino-5-Hydroxyhexanoic Acid by Intramolecular Cycloaddition." Molecules 3, no. 3: 80-87.

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