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Molecules 2018, 23(8), 2067; https://doi.org/10.3390/molecules23082067

Synthesis, Spectroscopic Analysis and Assessment of the Biological Activity of New Hydrazine and Hydrazide Derivatives of 3-Formylchromone

1
Department of Bioinorganic Chemistry, Medical University of Lodz, Muszyńskiego 1, 90-151 Łódź, Poland
2
Department of Physical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 163/165, 90-236 Łódź, Poland
3
Department of Physics of Crystals, Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland
*
Author to whom correspondence should be addressed.
Received: 11 July 2018 / Revised: 12 August 2018 / Accepted: 15 August 2018 / Published: 17 August 2018
(This article belongs to the Section Medicinal Chemistry)
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Abstract

The hydrazine and hydrazide derivatives of benzo-γ-pyrones with fluorine substituents remain an unexplored group of chemical compounds. This preliminary study reports the synthesis, structural assessment, initial microbiological screening and biological testing of the synthesized compounds on cell lines using the XTT-assay. A series of 10 novel hydrazine and hydrazide derivatives of 3-formylchromone were synthesized and their structures determined. Structural assessment consisted of elemental analysis, IR, 1H-NMR, 13C-NMR, MS and crystallographic studies. Antimicrobial activity was tested on standard strains representing different groups of microorganisms. The tested compounds were found to inhibit microbial growth. Concentrations of 0.01–1250 µmol/L were found to influence cell proliferation, demonstrating antiproliferative and stimulation of proliferation against two cell lines: the L929 cell line (mouse fibroblast cell line) and the EA.hy926 cell line (the human umbilical vein, somatic cell hybrid). View Full-Text
Keywords: hydrazine; hydrazide; benzo-γ-pyrones; 3-formylchromone; XTT-assay; anti-proliferative activity hydrazine; hydrazide; benzo-γ-pyrones; 3-formylchromone; XTT-assay; anti-proliferative activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Słomiak, K.; Łazarenkow, A.; Chęcińska, L.; Kusz, J.; Ochocki, J.; Nawrot-Modranka, J. Synthesis, Spectroscopic Analysis and Assessment of the Biological Activity of New Hydrazine and Hydrazide Derivatives of 3-Formylchromone. Molecules 2018, 23, 2067.

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