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Molecules 2018, 23(8), 2053; https://doi.org/10.3390/molecules23082053

Biopesticide Activity from Drimanic Compounds to Control Tomato Pathogens

1
Escuela de Obstetricia y Puericultura, Facultad de Medicina, Universidad de Valparaíso, Angamos 655, Reñaca, Viña del Mar 2520000, Chile
2
Departamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avenida Leopoldo Carvallo 270, Playa Ancha, Valparaíso 2340000, Chile
3
Facultad de Farmacia, Universidad de Valparaíso, Avenida Gran Bretaña 1093, Valparaíso 2340000, Chile
4
Centro de Investigación Farmacopea Chilena (CIFAR), Universidad de Valparaíso, Santa Marta 183, Playa Ancha, Valparaíso 2340000, Chile
5
Laboratorio de Microbiología Molecular y Biotecnología Ambiental, Departamento de Química & Centro de Biotecnología “Dr. Daniel Alkalay Lowitt”, Universidad Técnica Federico Santa María, Avenida España 1680, Valparaíso 2340000, Chile
6
Escuela de Agronomía Pontificia Universidad Católica de Valparaíso, Quillota, SanFrancisco s/n La Palma, Quillota 2260000, Chile
7
Instituto de Investigaciones Agropecuarias INIA Centro Regional La Cruz, Chorrillos 86, La Cruz 2280000, Chile
8
Centro de Biotecnología “Dr. Daniel Alkalay Lowitt”, Universidad Técnica Federico Santa María, Avenida España 1680, Valparaíso 2340000, Chile
9
Center for Integrative Medicine and Innovative Science (CIMIS), Facultad de Medicina, Universidad Andrés Bello, Santiago 8320000, Chile
*
Authors to whom correspondence should be addressed.
Received: 24 July 2018 / Revised: 6 August 2018 / Accepted: 14 August 2018 / Published: 16 August 2018
(This article belongs to the Special Issue Natural Active Agents Against Bacteria, Fungi and Parasites)
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Abstract

Tomato crops can be affected by several infectious diseases produced by bacteria, fungi, and oomycetes. Four phytopathogens are of special concern because of the major economic losses they generate worldwide in tomato production; Clavibacter michiganensis subsp. michiganensis and Pseudomonas syringae pv. tomato, causative agents behind two highly destructive diseases, bacterial canker and bacterial speck, respectively; fungus Fusarium oxysporum f. sp. lycopersici that causes Fusarium Wilt, which strongly affects tomato crops; and finally, Phytophthora spp., which affect both potato and tomato crops. Polygodial (1), drimenol (2), isonordrimenone (3), and nordrimenone (4) were studied against these four phytopathogenic microorganisms. Among them, compound 1, obtained from Drimys winteri Forst, and synthetic compound 4 are shown here to have potent activity. Most promisingly, the results showed that compounds 1 and 4 affect Clavibacter michiganensis growth at minimal inhibitory concentrations (MIC) values of 16 and 32 µg/mL, respectively, and high antimycotic activity against Fusarium oxysporum and Phytophthora spp. with MIC of 64 µg/mL. The results of the present study suggest novel treatment alternatives with drimane compounds against bacterial and fungal plant pathogens. View Full-Text
Keywords: polygodial; isonordrimenone; drimenol; clavibacter michiganensis; Pseudomonas syringae pv. tomato; Fusarium oxysporum; Phytophthora polygodial; isonordrimenone; drimenol; clavibacter michiganensis; Pseudomonas syringae pv. tomato; Fusarium oxysporum; Phytophthora
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Montenegro, I.; Madrid, A.; Cuellar, M.; Seeger, M.; Alfaro, J.F.; Besoain, X.; Martínez, J.P.; Ramirez, I.; Olguín, Y.; Valenzuela, M. Biopesticide Activity from Drimanic Compounds to Control Tomato Pathogens. Molecules 2018, 23, 2053.

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