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Molecules 2018, 23(8), 2035; https://doi.org/10.3390/molecules23082035

Effect of Different Anthocyanidin Glucosides on Lutein Uptake by Caco-2 Cells, and Their Combined Activities on Anti-Oxidation and Anti-Inflammation In Vitro and Ex Vivo

1
Food and Health Cluster, School of Chemical Engineering, UNSW, Sydney, NSW 2052, Australia
2
Mark Wainwright Analytical Centre, UNSW, Sydney, NSW 2052, Australia
*
Authors to whom correspondence should be addressed.
Academic Editors: Natália Martins and Derek J. McPhee
Received: 23 July 2018 / Revised: 6 August 2018 / Accepted: 11 August 2018 / Published: 14 August 2018
(This article belongs to the Special Issue Bioactive Plant Compounds for Sustainable Health)
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Abstract

The interactive effects on anti-oxidation and anti-inflammation of lutein combined with each of the six common anthocyanidin glucosides were studied in both chemical and cellular systems. The combined phytochemicals showed an antagonism in the inhibition of lipid oxidation in a liposomal membrane, but showed an additive effect on cellular antioxidant activity in Caco-2 cells. Lutein was an active lipoxygenase inhibitor at 2–12 μM while anthocyanins were inactive. The concentration of lutein when it was used in combination with anthocyanins was 25–54% higher than when lutein was used alone (i.e., IC50 = 1.2 μM) to induce 50% of lipoxygenase inhibition. Only the combination of lutein with malvidin-3-glucoside showed anti-inflammatory synergy in the suppression of interleukin-8, and the synergy was seen at all three ratios tested. Some mixtures, however, showed anti-inflammatory antagonism. The presence of anthocyanins (5–7.5 μM) did not affect lutein uptake (2.5–5 μM) by Caco-2 cells. View Full-Text
Keywords: anthocyanins; lutein; interaction; cellular antioxidant activity; anti-inflammatory activity; cellular uptake interference anthocyanins; lutein; interaction; cellular antioxidant activity; anti-inflammatory activity; cellular uptake interference
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Phan, M.A.T.; Bucknall, M.; Arcot, J. Effect of Different Anthocyanidin Glucosides on Lutein Uptake by Caco-2 Cells, and Their Combined Activities on Anti-Oxidation and Anti-Inflammation In Vitro and Ex Vivo. Molecules 2018, 23, 2035.

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