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Molecules 2018, 23(7), 1709; https://doi.org/10.3390/molecules23071709

Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis

1
The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
2
Syngenta Jealott’s Hill International Research Centre, Berkshire RG42 6EY, UK
3
Sichuan Institute of Food and Drug Control, Chengdu 611731, China
*
Authors to whom correspondence should be addressed.
Received: 21 June 2018 / Revised: 6 July 2018 / Accepted: 7 July 2018 / Published: 13 July 2018
(This article belongs to the Special Issue Antitumoral Properties of Natural Products)
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Abstract

Five new polyketides, including two pairs of enantiomers and a racemate, were isolated from the fermentation broth of Aspergillus fumigatus, an endophytic fungus isolated from Cordyceps sinensis. Their structures were identified using one-dimensional (1D) and two-dimensional (2D) NMR experiments, and the absolute configurations of the enantiomers were confirmed using electronic circular dichroism (ECD) calculations. Compounds 1a and 2a exhibited inhibitory activity against the MV4-11 cell line in vitro, with IC50 values of 23.95 µM and 32.70 µM, respectively. View Full-Text
Keywords: Aspergillus fumigatus; Cordyceps sinensis; isochromanes; chiral resolution; ECD calculation; cytotoxicity Aspergillus fumigatus; Cordyceps sinensis; isochromanes; chiral resolution; ECD calculation; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Guo, D.-L.; Li, X.-H.; Feng, D.; Jin, M.-Y.; Cao, Y.-M.; Cao, Z.-X.; Gu, Y.-C.; Geng, Z.; Deng, F.; Deng, Y. Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis. Molecules 2018, 23, 1709.

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