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Molecules 2018, 23(7), 1665; https://doi.org/10.3390/molecules23071665

Interleukin-33: Its Emerging Role in Allergic Diseases

1
Department of Pathophysiology, Medical College, Nanchang University, 461 Bayi Road, Nanchang 330006, China
2
Gannan Medical University, Rongjiang New Area, Ganzhou 341000, China
*
Author to whom correspondence should be addressed.
Received: 11 June 2018 / Revised: 5 July 2018 / Accepted: 6 July 2018 / Published: 9 July 2018
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Abstract

Allergic diseases, which include asthma, allergic rhinitis (AR), chronic rhinosinusitis (CRS), atopic dermatitis (AD), food allergy (FA), allergic keratoconjunctivitis, seriously affect the quality of life of people all over the world. Recently, interleukin-33 (IL-33) has been found to play an important role in these refractory disorders, mainly by inducing T helper (Th) 2 immune responses. This article reviews the mobilization and biological function of IL-33 in allergic disorders, providing novel insights for addressing these hypersensitive conditions. View Full-Text
Keywords: interleukin-33; allergic diseases; target therapy; asthma; Th2-type immunity interleukin-33; allergic diseases; target therapy; asthma; Th2-type immunity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Ding, W.; Zou, G.-L.; Zhang, W.; Lai, X.-N.; Chen, H.-W.; Xiong, L.-X. Interleukin-33: Its Emerging Role in Allergic Diseases. Molecules 2018, 23, 1665.

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