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Molecules 2018, 23(7), 1624; https://doi.org/10.3390/molecules23071624

Isolation, Structural Elucidation of Three New Triterpenoids from the Stems and Leaves of Schisandra chinensis (Turcz) Baill.

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China
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Received: 13 June 2018 / Revised: 26 June 2018 / Accepted: 27 June 2018 / Published: 4 July 2018
(This article belongs to the Collection Triterpenes and Triterpenoids)
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Abstract

Schisandra chinensis (Turcz) Baill. is sufficiently well known as a medicinal plant worldwide, which modern research shows has many pharmacological activities such as hepatoprotective, anti-inflammatory effect, potent anti-HIV-1 activity, anti-tumor effect, and activity on the central nervous system. With considerable chemical investigation, three new triterpenoids (13), together with four known triterpenoids were isolated from the S. chinensis (Turcz) Baill. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analyses, single-crystal X-ray diffraction and high-resolution mass spectroscopy, which were identified as Schisanlactone I (1), Schinalactone D, (2), Schisanlactone J, (3) Kadsuphilactone B (4), Schisanlactone C (5), Schisphendilactone B (6), and Schinchinenlactone A (7). The cytotoxicity of those compounds (17) was tested against Hep-G2 cell lines, but no apparent antitumor activity was observed at 50 µg/mL using MTT method. View Full-Text
Keywords: Schisandra chinensis (Turcz) Baill.; triterpenoids; cytotoxicity Schisandra chinensis (Turcz) Baill.; triterpenoids; cytotoxicity
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Qiu, F.; Liu, H.; Duan, H.; Chen, P.; Lu, S.-J.; Yang, G.-Z.; Lei, X.-X. Isolation, Structural Elucidation of Three New Triterpenoids from the Stems and Leaves of Schisandra chinensis (Turcz) Baill.. Molecules 2018, 23, 1624.

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