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Molecules 2016, 21(12), 1700; doi:10.3390/molecules21121700

Six New Triterpene Derivatives from Aralia chinensis Var. dasyphylloides

1
Laboratory for Natural Product Chemistry, College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China
2
College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China
3
College of Chemistry and Material Sciences, South-Central University for Nationalities, Wuhan 430074, China
*
Author to whom correspondence should be addressed.
Academic Editor: Efstathia Ioannou
Received: 27 October 2016 / Revised: 2 December 2016 / Accepted: 2 December 2016 / Published: 9 December 2016
(This article belongs to the Special Issue Triterpenes and Triterpenoids 2016)
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Abstract

Aralia chinensis var. dasyphylloides is widely distributed in China and used as a traditional herbal medicine for the treatment of digestive and immune system diseases. The present study aimed to search for novel oleanolic-type triterpenoids in low-polarity fractions. Six new triterpene derivatives (16), together with two known compounds were isolated from the barks of A. chinensis var. dasyphylloides. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analysis and chemical methods. They were identified as 3-oxo-oleana-11,13(18)-dien-28,30-dioic acid (1), 30-hydroxy-3-oxo-oleana-11,13(18)-dien-28-oic acid (2), 3β-hydroxy-oleana-11,13(18)-dien-28-oic acid-28-O-β-d-glucopyranoside (3), 3β,30-dihydroxy-oleana-11,13(18)-dien-28-oic acid-28-O-β-d-glucopyranoside (4), 3β-hydroxy-oleana-11,13(18)-dien-28-oic acid-3-O-β-d-xylopyranosyl-(1 → 2)-β-d-glucopyranoside (5), 3β,29-dihydroxy-oleana-9(11),12-dien-28-oic acid-28-O-β-d-glucopyranoside (6), namely, araliachinolic acids I and II and araliachinosides I–IV. The cytotoxicity of the isolated compounds was tested against HepG2, A549, SGC7901, and MCF7 cell lines, but no apparent activity was observed at a concentration of 50 μM. View Full-Text
Keywords: Aralia chinensis var. dasyphylloides; triterpene derivatives; araliachinolic acids I and II; araliachinosides I–IV Aralia chinensis var. dasyphylloides; triterpene derivatives; araliachinolic acids I and II; araliachinosides I–IV
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MDPI and ACS Style

Gao, R.-X.; Liao, M.; Huang, X.; Chen, Y.; Yang, G.; Li, J. Six New Triterpene Derivatives from Aralia chinensis Var. dasyphylloides. Molecules 2016, 21, 1700.

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