Next Article in Journal
Iron Oxide Nanoparticles in Photothermal Therapy
Next Article in Special Issue
Isolation and Evaluation of Bioactive Protein and Peptide from Domestic Animals’ Bone Marrow
Previous Article in Journal
Study on Hybrid Characteristics of Medicinally Used Cultivated Codonopsis Species Using Ribosomal Internal Transcribed Spacer (ITS) Sequencing
Previous Article in Special Issue
Antifungal Activity of an Abundant Thaumatin-Like Protein from Banana against Penicillium expansum, and Its Possible Mechanisms of Action
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessFeature PaperArticle
Molecules 2018, 23(7), 1566; https://doi.org/10.3390/molecules23071566

Synthesis of Antibacterial Nisin–Peptoid Hybrids Using Click Methodology

1
Center for Global Infectious Diseases, Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK
2
Department of Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 31 May 2018 / Revised: 18 June 2018 / Accepted: 21 June 2018 / Published: 28 June 2018
(This article belongs to the Special Issue Antimicrobial Peptides and Peptidomimetics)
Full-Text   |   PDF [1021 KB, uploaded 28 June 2018]   |  

Abstract

Antimicrobial peptides and structurally related peptoids offer potential for the development of new antibiotics. However, progress has been hindered by challenges presented by poor in vivo stability (peptides) or lack of selectivity (peptoids). Herein, we have developed a process to prepare novel hybrid antibacterial agents that combine both linear peptoids (increased in vivo stability compared to peptides) and a nisin fragment (lipid II targeting domain). The hybrid nisin–peptoids prepared were shown to have low micromolar activity (comparable to natural nisin) against methicillin-resistant Staphylococcus aureus. View Full-Text
Keywords: peptoids; peptoid–peptide hybrid; nisin; antibacterial; alkyne-azide click reactions peptoids; peptoid–peptide hybrid; nisin; antibacterial; alkyne-azide click reactions
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Bolt, H.L.; Kleijn, L.H.J.; Martin, N.I.; Cobb, S.L. Synthesis of Antibacterial Nisin–Peptoid Hybrids Using Click Methodology. Molecules 2018, 23, 1566.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top