Next Article in Journal
Investigations of Structural Requirements for BRD4 Inhibitors through Ligand- and Structure-Based 3D QSAR Approaches
Next Article in Special Issue
(+)-epi-Epoformin, a Phytotoxic Fungal Cyclohexenepoxide: Structure Activity Relationships
Previous Article in Journal
Discovery of the Potential Biomarkers for Discrimination between Hedyotis diffusa and Hedyotis corymbosa by UPLC-QTOF/MS Metabolome Analysis
Previous Article in Special Issue
Structure-Dependent Activity of Natural GABA(A) Receptor Modulators
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessFeature PaperReview
Molecules 2018, 23(7), 1526; https://doi.org/10.3390/molecules23071526

Structure-Activity Relationship of Cannabis Derived Compounds for the Treatment of Neuronal Activity-Related Diseases

1
Department of Chemistry, University of Turin, 10125 Torino, Italy
2
ARO, Volcani Center, Rishon LeZion 7505101, Israel
*
Author to whom correspondence should be addressed.
Academic Editor: Antonio Evidente
Received: 22 May 2018 / Revised: 21 June 2018 / Accepted: 23 June 2018 / Published: 25 June 2018
(This article belongs to the Special Issue Structure-Activity Relationship of Natural Products 2018)
Full-Text   |   PDF [3800 KB, uploaded 25 June 2018]   |  

Abstract

Cannabis sativa active compounds are extensively studied for their therapeutic effects, beyond the well-known psychotropic activity. C. Sativa is used to treat different medical indications, such as multiple sclerosis, spasticity, epilepsy, ulcerative colitis and pain. Simultaneously, basic research is discovering new constituents of cannabis-derived compounds and their receptors capable of neuroprotection and neuronal activity modulation. The function of the various phytochemicals in different therapeutic processes is not fully understood, but their significant role is starting to emerge and be appreciated. In this review, we will consider the structure-activity relationship (SAR) of cannabinoid compounds able to bind to cannabinoid receptors and act as therapeutic agents in neuronal diseases, e.g., Parkinson’s disease. View Full-Text
Keywords: Cannabis sativa; structure-activity relationship; phytocannabinoids; endocannabinoids; cannabinoid receptors; neuronal diseases; Parkinson’s disease Cannabis sativa; structure-activity relationship; phytocannabinoids; endocannabinoids; cannabinoid receptors; neuronal diseases; Parkinson’s disease
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Prandi, C.; Blangetti, M.; Namdar, D.; Koltai, H. Structure-Activity Relationship of Cannabis Derived Compounds for the Treatment of Neuronal Activity-Related Diseases. Molecules 2018, 23, 1526.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top