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Molecules 2018, 23(6), 1486; https://doi.org/10.3390/molecules23061486

Mitochondria-Targeting Small Molecules Effectively Prevent Cardiotoxicity Induced by Doxorubicin

1
Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai 519041, China
2
School of Life Sciences, Shandong University of Technology, Zibo 255000, China
3
Pharmacy School, Zunyi Medical University, Zunyi 563003, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Simona Collina and Mariarosaria Miloso
Received: 22 May 2018 / Revised: 13 June 2018 / Accepted: 13 June 2018 / Published: 19 June 2018
(This article belongs to the Special Issue Recent Advances in Anticancer Drugs)
Full-Text   |   PDF [872 KB, uploaded 19 June 2018]   |  

Abstract

Doxorubicin (Dox) is a chemotherapeutic agent widely used for the treatment of numerous cancers. However, the clinical use of Dox is limited by its unwanted cardiotoxicity. Mitochondrial dysfunction has been associated with Dox-induced cardiotoxicity. To mitigate Dox-related cardiotoxicity, considerable successful examples of a variety of small molecules that target mitochondria to modulate Dox-induced cardiotoxicity have appeared in recent years. Here, we review the related literatures and discuss the evidence showing that mitochondria-targeting small molecules are promising cardioprotective agents against Dox-induced cardiac events. View Full-Text
Keywords: doxorubicin; cardiotoxicity; mitochondria; small molecules doxorubicin; cardiotoxicity; mitochondria; small molecules
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Shi, W.; Deng, H.; Zhang, J.; Zhang, Y.; Zhang, X.; Cui, G. Mitochondria-Targeting Small Molecules Effectively Prevent Cardiotoxicity Induced by Doxorubicin. Molecules 2018, 23, 1486.

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