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Molecules 2018, 23(6), 1434; https://doi.org/10.3390/molecules23061434

Correlation of FT-IR Fingerprint and α-Glucosidase Inhibitory Activity of Salak (Salacca zalacca) Fruit Extracts Utilizing Orthogonal Partial Least Square

1
Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Indera Mahkota, Kuantan 25200, Pahang, Malaysia
2
Laboratoire de Synthèse Organique Appliquée, Faculté des Sciences Exactes et Appliquées, Département de Chimie, Université Oran1, BP 1524 El Mnaoueur, 31000 Oran, Algérie
*
Author to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Received: 5 May 2018 / Revised: 4 June 2018 / Accepted: 5 June 2018 / Published: 13 June 2018
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Abstract

Salak fruit (Salacca zalacca), commonly known as snake fruit, is used indigenously as food and for medicinal applications in Southeast Asia. This study was conducted to evaluate the α-glucosidase inhibitory activity of salak fruit extracts in correlation to its Fourier transform infrared spectroscopy (FT-IR) fingerprint, utilizing orthogonal partial least square. This calibration model was applied to develop a rapid analytical method tool for quality control of this fruit. A total of 36 extracts prepared with different solvent ratios of ethanol–water (100, 80, 60, 40.20, 0% v/v) and their α-glucosidase inhibitory activities determined. The FT-IR spectra of ethanol–water extracts measured in the region of 400 and 4000 cm−1 at a resolution of 4 cm−1. Multivariate analysis with a combination of orthogonal partial least-squares (OPLS) algorithm was used to correlate the bioactivity of the samples with the FT-IR spectral data. The OPLS biplot model identified several functional groups (C–H, C=O, C–N, N–H, C–O, and C=C) which actively induced α-glucosidase inhibitory activity. View Full-Text
Keywords: α-glucosidase inhibitory activity; fingerprint; Fourier transform infrared spectroscopy; salak fruit α-glucosidase inhibitory activity; fingerprint; Fourier transform infrared spectroscopy; salak fruit
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Saleh, M.S.M.; Siddiqui, M.J.; Mat So’ad, S.Z.; Roheem, F.O.; Saidi-Besbes, S.; Khatib, A. Correlation of FT-IR Fingerprint and α-Glucosidase Inhibitory Activity of Salak (Salacca zalacca) Fruit Extracts Utilizing Orthogonal Partial Least Square. Molecules 2018, 23, 1434.

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