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Molecules 2018, 23(6), 1339;

Indium-Catalyzed Direct Conversion of Lactones into Thiolactones Using a Disilathiane as a Sulfur Source

Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan
Author to whom correspondence should be addressed.
Received: 16 May 2018 / Revised: 29 May 2018 / Accepted: 1 June 2018 / Published: 2 June 2018
(This article belongs to the Special Issue Indium in Organic Synthesis)
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An indium-catalyzed reaction of lactones and a disilathiane leading to thiolactones is described. The direct synthesis of thiolactones from lactones with an appropriate sulfur source is one of the most attractive approaches in organic and pharmaceutical chemistry. In this context, we found an indium-catalyzed direct conversion of lactones into thiolactones in the presence of elemental sulfur and a hydrosilane via formation of the disilathiane in situ. On the basis of the previous reaction, the application utilizing the disilathiane as a sulfur source was performed herein for the efficient synthesis of a variety of thiolactone derivatives from lactones by an indium catalyst. View Full-Text
Keywords: indium catalyst; disilathiane; lactones; thiolactones indium catalyst; disilathiane; lactones; thiolactones

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ogiwara, Y.; Takano, K.; Horikawa, S.; Sakai, N. Indium-Catalyzed Direct Conversion of Lactones into Thiolactones Using a Disilathiane as a Sulfur Source. Molecules 2018, 23, 1339.

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